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Award-winning research goes deep with neural networks for drug safety

Austin Daniels, Chris Calderone and Ted Randolph

Researchers Austin Daniels, Chris Calderon and Ted Randolph

A team from the Department of Chemical and Biological Engineering received one of the pharmaceutical industry鈥檚 top honors鈥攖he Ebert Prize鈥攆or using deep neural networks to analyze images of sensitive protein-based drugs. The Ebert Prize, established in 1873, is the oldest continuously awarded pharmacy award in the United States.

Lead author Adjunct Assistant Professor Chris Calderon, Gillespie Professor Ted Randolph and graduate student Austin Daniels authored the prize-winning research, in the April 2018 issue of the Journal of Pharmaceutical Science.

Protein-based drugs comprise the fastest-growing class of pharmaceuticals and provide remarkable benefits for human health, but they are also highly susceptible to damage while traveling from the production line to the patient.

鈥淒ifferent protein stresses鈥攊ncluding mechanical agitation and temperature shock鈥攃an cause protein therapeutics to degrade,鈥 Calderon said. 鈥淐ertain types of stressed protein drugs can even cause adverse reactions, including death. Since protein therapeutics are often sensitive to their environment, characterizing their stability and quality at different stages of production and storage is crucial.鈥

The team used an innovative combination of deep neural network image analysis鈥攗tilizing machine-learning algorithms for image and speech recognition鈥攚ith computational statistics, biophysics and protein engineering methods to evaluate and characterize impurities and contaminants within proteins engineered for pharmaceutical use.

鈥淲e demonstrate a new approach for extracting information about the quality and stability of protein-based drug formulations from images measured with a high-throughput, microfluidic microscope,鈥 Calderon said.

鈥淔acial recognition technologies and other machine learning techniques may seem far apart from traditionally used methods听to develop stable formulations of protein drugs,鈥 Randolph elaborated. 鈥淏ut the beauty of combining these seemingly disparate approaches is that it generates new insights into challenging problems听and opens up whole new avenues for research. For example, we are now examining how the combined techniques may address issues associated with neonatal blood infections.鈥

Calderon credits the diversity and positive collaborative environment of the department for fostering this combined-discipline approach. Glenn L. Murphy Endowed Professor Daniel Schwartz connected Calderon and Randolph when he realized that the two professors might benefit from working together.

鈥淭he resulting collaboration has taught me a lot about protein therapeutics and continues to show promise in multiple avenues,鈥 Calderon said. 鈥淥ur collaboration probably wouldn鈥檛 have happened without Dan catalyzing this meeting, and it serves as a nice example of the interdisciplinary research potential at ChBE.鈥

The team will receive the Ebert Prize at the Annual Meeting of the American Pharmacists Association in Seattle in March.