Kaar

Sanchez-Moran's enzyme immobilization research takes top prize at biologics summit

Anonymous — Fri, 26 May 2023 16:21:24 +0000

Sanchez-Moran's enzyme immobilization research takes top prize at biologics summit Anonymous (not verified) Fri, 05/26/2023 - 10:21

Susan Glairon

Surpassing more than 300 participants, chemical engineering PhD student Hector Sanchez-Moran took home first prize at the PEGS Essential Protein and Antibody Engineering Summit poster presentation competition. The summit took place from May 15-19 in Boston.

Sanchez-Moran's said his poster explored significant advancements in the field of enzyme immobilization and its applications.

"This award signifies recognition for my years of research in the Kaar and Schwartz labs," said Sanchez-Moran, who is co-advised by Professor Daniel Schwartz and Associate Professor Joel Kaar. "The award, along with the enthusiastic responses from individuals I engaged with regarding my poster, demonstrates the value the biotechnology community places on our work, highlighting the significant implications of efficient enzyme immobilization."

The summit bills itself as "the leading biologics event," with comprehensive programming covering biologic drug development, including in-depth presentations on protein and antibody engineering, immunotherapy, oncology, expression, analytics and immunogenicity.

Enzyme immobilization has been extensively employed by protein engineers for a variety of applications, including bioremediation, biosensors and industrial biocatalysts. However, the precise understanding of how enzyme immobilization and its applications interact is not yet well understood, Sanchez-Moran said. His poster shed light on the complex nanoscale stabilizing interactions that lead to the remarkable stabilization of important enzymes used in detergent production, pharmaceutical manufacturing and the food industry. While these enzymes are barely stable above body temperature, Sanchez-Moran's immobilization technique demonstrated the ability to maintain their functionality up to boiling temperatures, thereby enhancing their utility in industrial settings.

Sanchez-Moran said it was his first experience attending a conference with significant industry participation.

"It was interesting to present my poster alongside representatives from leading biotech companies and engage in conversations about their own technologies," he said. "It's fascinating to observe the delicate balance these companies maintain, walking the fine line between disseminating their findings while protecting crucial information regarding their intellectual property."

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PhD student honored for shape-changing “smart” materials research

Anonymous — Thu, 13 Apr 2023 16:42:02 +0000

PhD student honored for shape-changing “smart” materials research Anonymous (not verified) Thu, 04/13/2023 - 10:42

Susan Glairon

PhD Student Albert Velasco Abadia was awarded the prestigious Materials Research Society (MRS) Graduate Student Gold Award for his research in using biological catalysts — also known as enzymes — for triggering shape reconfigurations in liquid crystal network "smart" materials.

These materials change shape in response to heat or light, with the movement used for actuation of robotics.

Velasco Abadia, who is advised by Associate Professor Joel Kaar and Professor Dan Schwartz, was first chosen as a finalist for the MRS Graduate Student Award and then invited to present his research at the society’s spring conference in San Francisco on April 13. He was awarded the highest graduate student honor on the basis of his talk.

"This award means a lot to me," Velasco Abadia said. "It recognizes the teamwork of Dan (Schwartz) and Joel (Kaar), and the work we are doing in cooperation with Tim White. It shows collaboration within the department really works."

Schwartz said Velasco Abadia initiated and led an entirely new project in his lab, collaborating with the White Group to immobilize enzymes within liquid crystal networks and creating a new class of responsive materials. While previous liquid crystal networks had been designed to respond to simple chemical cues, such as acids or bases, Velasco Abadia created shape- and color-changing materials that react to diverse and specific biochemical signals, directly relevant to biomedical and environmental applications.

Velasco Abadia said the research could be potentially applicable in tissue engineering, such as coronary stents that automatically expand on encountering fatty plaque, or in drug delivery, with the materials "knowing" the amount of glucose in a diabetic person's body and then releasing insulin when needed.

Because this project intersected biomolecular and materials science research, Velasco Abadia was required to develop wide-ranging expertise in modifying and expressing proteins, synthesizing liquid crystal materials, designing shape-changing constructs and characterizing the chemical, mechanical and catalytic properties of the resulting materials and constructs, Schwartz said.

"Albert has been an incredibly creative and productive researcher," he said. "He deserves full credit for his success, frequently bringing new ideas and interpretations to his research. I can’t recall another student who brought the same level of chemical sophistication and initiative. In many ways, supervising Albert has felt more like a collaboration with a peer than mentoring a student."

Velasco Abadia also recently won an American Chemical Society (ACS) award for excellence in graduate polymer research and was invited to give a talk at the ACS spring meeting. He plans to complete his PhD in biological engineering in June.

"I want to thank both my advisors — they have always supported me — and my labmates and my collaborators in the R+PM Lab," Velasco Abadia said. "No one had put enzymes in these materials before us. There was a lot of skepticism whether it would work, but we showed we could make this work.”

PhD Student Albert Velasco Abadia was awarded the prestigious Materials Research Society Graduate Student Gold Award for his research in using biological catalysts — also known as enzymes — for triggering shape reconfigurations in "smart" materials known as liquid crystal networks.

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Kaar joins team using NSF grant to develop "on-demand, on-site" mRNA creation

Anonymous — Tue, 21 Sep 2021 19:43:41 +0000

Kaar joins team using NSF grant to develop "on-demand, on-site" mRNA creation Anonymous (not verified) Tue, 09/21/2021 - 13:43

Jonathan Raab

COVID-19 vaccines are just the beginning for mRNA-based therapies; enabling a patient’s body to make almost any given protein could revolutionize care for other viruses, like HIV, as well as various cancers and genetic disorders. However, because mRNA molecules are very fragile, they require extremely low temperatures for storage and transportation. The logistical challenges and expense of maintaining these temperatures must be overcome before mRNA therapies can become truly widespread.

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