Senescence Evasion in Chemotherapy: A Sweet Spot for p21 (Cell)
![Time-lapse imaging, p21, cancer cells, senescence, cell-cycle re-entry, drug treatment](/lab/spencerlab/sites/default/files/styles/large_image_style/public/article-image/ashraf_et_al._2019_figure_1.jpg?itok=AyG1DVxg)
Time-lapse imaging reveals a nuanced role for  in cancer cells challenged with chemotherapeutic drugs: cells with either high or low p21 are biased toward senescence, whereas intermediate p21 allows cells to re-enter the cell cycle after drug treatment.