Stem Cells News
November 2024
ESC and iSPC
- In Vitro Gametogenesis: Towards Competent Oocytes,, BioEssays
- Microcell-Mediated Chromosome Transfer Between Non-Identical Human iPSCs,, Molecular Therapy – Nucleic Acids
- Blastoid: The Future of Human Development in the Laboratory,, Cells & Development
- Proteomic and Functional Comparison Between Human Induced and Embryonic Stem Cells,, eLife
- A Comprehensive Human Embryo Reference Tool Using Single-Cell RNA-Sequencing Data,, Nature Methods
- Proteomic and Functional Comparison Between Human Induced and Embryonic Stem Cells,, eLife
- A Comprehensive Human Embryo Reference Tool Using Single-Cell RNA-Sequencing Data,, Nature Methods
- Inhibition of Lung Tumorigenesis by Transient Reprogramming in Cancer Cells,, Cell Death & Disease
Neural
- Human iPSC-Derived Neural Stem Cells Displaying Radial Glia Signature Exhibit Long-Term Safety in Mice,, Nature Communications
- First Patient Takes Part in New Phase I Clinical Trial for Patients with Recurrent Glioblastoma,, UCLH NHS Foundation Trust
- Effects of Microgravity on Human iPSC-Derived Neural Organoids on the International Space Station,, Stem Cells Translational Medicine
- Parkinson Disease Therapy: Current Strategies and Future Research Priorities,, Nature Reviews Neurology
- New Vaccines Offer Hope for Brain Tumor Patients,, German Cancer Research Center (DKFZ)
- White Matter Aging and Its Impact on Brain Function,, Neuron
- Astrocytic Proteostasis in the Tale of Aging and Neurodegeneration,, Ageing Research Reviews
Cell Therapy
- Intracavernosal Mesenchymal Stem Cell Therapy in Ischemic Priapism: An Experimental Study,, International Urology and Nephrology
- Solid Tumor Immunotherapy Using NKG2D-Based Adaptor CAR T Cells,, Cell Reports Medicine
- Phenotypic Insights into Genetic Risk Factors for Immune-Related Adverse Events in Cancer Immunotherapy,, Cancer Immunology Immunotherapy
- CAR T Cells and T Cell Therapies for Cancer,, Jama-Journal of The American Medical Association
- Single-Stranded DNA with Internal Base Modifications Mediates Highly Efficient Knock-In in Primary Cells Using CRISPR-Cas9,, Nucleic Acids Research
- Resistance to Immunomodulatory Drugs in Multiple Myeloma: The Cereblon Pathway and Beyond,, Haematologica
- Rational Design of Advanced Gene Delivery Carriers: Macrophage Phenotype Matters,, Advanced Materials
Organoids
- Human Immune Organoids to Decode B Cell Response in Healthy Donors and Patients with Lymphoma,, Nature Materials
- The Culture and Application of Circulating Tumor Cell-Derived Organoids,, Trends in Cell Biology
- Advancing Cancer Research through Organoid Technology,, Journal of Translational Medicine
- Organoids and Organoid Extracellular Vesicles-Based Disease Treatment Strategies,, Journal of Nanobiotechnology
- Physiological Modeling of the Vascularized Human Lung Organoid,, American Journal of Respiratory Cell and Molecular Biology
- Organoid Models of Breast Cancer in Precision Medicine and Translational Research,, Molecular Biology Reports
October 2024
ESC and iPSC
- Transient Promoter Interactions Modulate Developmental Gene Activation,, Molecular Cell
- Lateral Cell Polarization Drives Organization of Epithelia in Sea Anemone Embryos and Embryonic Cell Aggregates,, Proceedings of The National Academy of Sciences of The United States of America
- Human In Vitro Models for Fabry Disease: New Paths for Unravelling Disease Mechanisms and Therapies,, Journal of Translational Medicine
- Axol Bioscience Acquires Phenocell to Advance Human Disease Models,, Axol, Ltd. (Business Wire)
- How Much Energy Does It Take to Make a Baby? Researchers Are Rethinking What They Know,, Nature
- Genome-Wide Mapping of Native Co-Localized G4s and R-Loops in Living Cells,, eLife
- Early Human Development and Stem Cell-Based Human Embryo Models,, Cell Stem Cell
- Induced Pluripotent Stem Cells Facilitate the Development and Evaluation of Cancer Vaccines,, Cancer Research
Neural
- Local Glycolysis Supports Injury-Induced Axonal Regeneration,, Journal of Cell Biology
- Researchers Close In on Understanding Possible Cause of Alzheimer’s Disease,, Case Western Reserve University
- Global Effort to Map the Human Brain Releases First Data,, Allen Institute
- Emerging Roles of Astrocytes as Immune Effectors in the Central Nervous System,, Trends In Immunology
- Neuronal Wiring Diagram of an Adult Brain,, Nature
- Leveraging Pleiotropy for the Improved Treatment of Psychiatric Disorders,, Molecular Psychiatry
- Glia in Tissue Engineering: From Biomaterial Tools to Transplantation,, Acta Biomaterialia
Cell Therapy
- Mechanical Strategies to Promote Vascularization for Tissue Engineering and Regenerative Medicine,, Burns & Trauma
- World-First Therapy Using Donor Cells Sends Autoimmune Diseases into Remission,, Nature News
- Cell Therapy for Neurological Disorders,, Nature Medicine
- Exosome-Based Cell Therapy for Diabetic Foot Ulcers: Present and Prospect,, Heliyon
- Glia in Tissue Engineering: From Biomaterial Tools to Transplantation,, Acta Biomaterialia
- Advances and Applications of RNA Vaccines in Tumor Treatment,, Molecular Cancer
- Long-Term Lineage Commitment in Hematopoietic Stem Cell Gene Therapy,, Nature
- Cationized Extracellular Vesicles for Gene Delivery,, Scientific Reports
Organoid
- Novel Human iPSC Models of Neuroinflammation in Neurodegenerative Disease and Regenerative Medicine,, Trends In Immunology
- Non-Invasive Label-Free Imaging Analysis Pipeline for In Situ Characterization of 3D Brain Organoids,, Scientific Reports
- Tuft Cells Act As Regenerative Stem Cells in the Human Intestine,, Nature
- Evaluating Neuroprivacy Concerns in Human Brain Organoid Research,, Trends In Biotechnology
- Organoid Modeling Meets Cancers of Female Reproductive Tract,, Cell Death Discovery
- Mini-Brain Pressure Models Compression Injuries,, Mirage
- Potential Use of Organoids in Regenerative Medicine,, Tissue Engineering and Regenerative Medicine
- Patient-Derived Organoids: A Game-Changer in Personalized Cancer Medicine,, Stem Cell Reviews and Reports
September 2024
ESC and iPSC
- Lab-Grown Stem Cells Could Be a ‘Breakthrough’ for Cancer Treatment,, NewScientist
- Microglial Drivers of Alzheimer’s Disease Pathology: An Evolution of Diverse Participating States,, Proteins-Structure Function and Bioinformatics
- Directed Differentiation of Human Embryonic Stem Cells into Conjunctival Epithelial Cells,, Experimental Cell Research
- The Pluripotent Path to Immunotherapy,, Experimental Hematology
- Parkinson’s iPSC Trial,, Nature Biotechnology
- Stem Cells Could Save the Giant Panda,, The Scientist
- The Power of Human Stem Cell-Based Systems in the Study of Neurodevelopmental Disorders,, Current Opinion In Neurobiology
Neural
- Aggregate-Selective Removal of Pathological Tau by Clustering-Activated Degraders,, Science
- Deciphering the Physiopathology of Neurodevelopmental Disorders Using Brain Organoids,, Brain
- Neural Circuitries between the Brain and Peripheral Solid Tumors,, Cancer Research
- Alzheimer’s Disease Biomarkers and Their Current Use in Clinical Research and Practice,, Molecular Psychiatry
- Glia in Neurodegenerative Disease,, Cold Spring Harbor Perspectives In Biology
- The Biology of Glia,, Cold Spring Harbor Perspectives In Biology
- The Power of Human Stem Cell-Based Systems in the Study of Neurodevelopmental Disorders,, Current Opinion In Neurobiology
Cell Therapy
- NF-κB-Activated Oncogene Inhibition Strategy for Cancer Gene Therapy,, nan
- Engineered T Cell Therapy for Central Nervous System Injury,, Nature
- The Pluripotent Path to Immunotherapy,, Experimental Hematology
- CAR-T Cell Therapy: Advances in Digestive System Malignant Tumors,, Molecular Therapy Oncology
- Therapeutic Efficacy of Intracerebral Hematopoietic Stem Cell Gene Therapy in an Alzheimer’s Disease Mouse Model,, Nature Communications
- Encapsulated Islet Transplantation,, Nature Reviews Bioengineering
Organoid
- Organoid as a Promising Tool for Primary Liver Cancer Research: A Comprehensive Review,, Cell & Bioscience
- Thymic Epithelial Organoids Mediate T Cell Development,, Development
- Neural Tube Organoids: A Novel System to Study Developmental Timing,, Stem Cell Reviews and Reports
- Brain Organoid Maturation and Implantation Integration Based on Electrical Signals Input,, Journal of Advanced Research
- The Landscape of Drug Sensitivity and Resistance in Sarcoma,, Cell Stem Cell
- Using Lab-Grown Organs to Test New Spider Venom Epilepsy Drugs,, Australian Institute for Bioengineering and Nanotechnology
August 2024
ESC and iPSC
- Dynamic Governance: A New Era for Consent for Stem Cell Research,, Stem Cell Reports
- The Fork Protection Complex Promotes Parental Histone Recycling and Epigenetic Memory,, Cell
- Pluripotent Stem Cell-Derived Organoids: A Brief History of Curiosity-Led Discoveries,, BioEssays
- Induced Pluripotent Stem Cells Facilitate the Development and Evaluation of Cancer Vaccines,, Cancer Research
- Substrates Mimicking the Blastocyst Geometry Revert Pluripotent Stem Cell to Naivety,, Nature Materials
- Combinatorial Regulatory States Define Cell Fate Diversity during Embryogenesis,, Nature Communications
- Individual Variation in the Emergence of Anterior-to-Posterior Neural Fates from Human Pluripotent Stem Cells,, Stem Cell Reports
- Patient iPSC Models Reveal Glia-Intrinsic Phenotypes in Multiple Sclerosis,, Cell Stem Cell
Neural
- A Functional Aged Human iPSC-Cortical Neuron Model Recapitulates Alzheimer’s Disease, Senescence, and the Response to Therapeutics,, Alzheimers & Dementia
- Mechanisms of Autophagy–Lysosome Dysfunction in Neurodegenerative Diseases,, Nature Reviews Molecular Cell Biology
- FDA Approves New Therapy for Glioma Patients for First Time in Decades,, Dana-Farber Cancer Institute
- Melatonin: A Potential Nighttime Guardian against Alzheimer’s,, Molecular Psychiatry
- FDA Rejects Ecstasy as a Therapy: What’s Next for Psychedelics?,, Nature
- Neuronal Maturation and Axon Regeneration: Unfixing Circuitry to Enable Repair,, Nature Reviews Neuroscience
- Tools to Study Neural and Glioma Stem Cell Quiescence,, Trends In Neurosciences
- Inflammatory Aspects of Alzheimer’s Disease,, Acta Neuropathologica
Cell Therapy
- Epigenome Editing Technologies for Discovery and Medicine,, Nature Biotechnology
- Quantifying Allele-Specific CRISPR Editing Activity with CRISPECTOR2.0,, Nucleic Acids Research
- Regenerative Cell Therapy with 3D Bioprinting,, Science
- Advancements and Challenges in Stem Cell Transplantation for Regenerative Medicine,, Heliyon
- Frontiers in CAR-T Cell Therapy for Autoimmune Diseases,, Trends In Pharmacological Sciences
- Applications of Cell Therapy in the Treatment of Virus-Associated Cancers,, Nature Reviews Clinical Oncology
- Modulating Elasticity of Liposome for Enhanced Cancer Immunotherapy,, ACS Nano
Organoid
- Researchers Receive McKnight Award to Study the Evolution of Deadly Brain Cancer,, UCLA Health
- Human Brain Organoids for Understanding Substance Use Disorders,, Drug Metabolism and Pharmacokinetics
- Radiation Response Assessment of Organoids Derived from Patients with Pancreatic Cancer,, Clinical and Translational Radiation Oncology
- Optimization of Vascularized Intestinal Organoid Model,, Advanced Healthcare Materials
- Research Progress of Brain Organoids in the Field of Diabetes,, Molecular Brain
- Liver Organoids: Updates on Generation Strategies and Biomedical Applications,, Stem Cell Research & Therapy
- Patient-Derived Organoid Models to Decode Liver Pathophysiology,, Trends In Endocrinology and Metabolism
- Mini-Brains Built From Blood: “Crazy Idea” Could Revolutionize Alzheimer’s Treatment,, SciTechDaily
July 2024
ESC and iPSC:
- Kidney Disease Modeling with Organoids and Organs-on-Chips, (Annual Review of Biomedical Engineering)
- Brain Chimeroids Reveal Individual Susceptibility to Neurotoxic Triggers,, (Nature)
- Breast Cancer Patient-Derived Organoids for the Investigation of Patient-Specific Tumour Evolution,, (Cancer Cell International)
- Unraveling Radiation-Induced Skeletal Muscle Damage: Insights from a 3D Human Skeletal Muscle Organoid Model,, (Biochimica Et Biophysica Acta-Molecular Cell Research)
- Utilizing Human Cerebral Organoids to Model Breast Cancer Brain Metastasis in Culture,, (Breast Cancer Research)
- Cancer Organoids 2.0: Modelling the Complexity of the Tumour Immune Microenvironment,, (Nature Reviews Cancer)
- Establishment of Advanced Tumor Organoids with Emerging Innovative Technologies,, (Cancer Letters)
- Isogenic Patient-Derived Organoids Reveal Early Neurodevelopmental Defects in Spinal Muscular Atrophy Initiation,, (Cell Reports Medicine)
Neural
- Adult-Onset Deactivation of Autophagy Leads to Loss of Synapse Homeostasis and Cognitive Impairment, with Implications for Alzheimer Disease,, Autophagy
- FDA Approves Eli Lilly’s Alzheimer’s Drug Kisunla,, NBC News
- Adenosine Signaling to Astrocytes Coordinates Brain Metabolism and Function,, Nature
- The Roles of Neural Stem Cells in Myelin Regeneration and Repair Therapy after Spinal Cord Injury,, Stem Cell Research & Therapy
- Cellular and Pathological Functions of Tau,, Nature Reviews Molecular Cell Biology
- Vaccine-Based Immunotherapy and Related Preclinical Models for Glioma,, Trends in Molecular Medicine
- The Prion-Like Effect and Prion-Like Protein Targeting Strategy in Amyotrophic Lateral Sclerosis,, Heliyon
- Single-Cell Multiregion Dissection of Alzheimer’s Disease,, Nature
- Human Microglial Cells as a Therapeutic Target in a Neurodevelopmental Disease Model,, Stem Cell Reports
- Nanozymes in Alzheimer’s Disease Diagnostics and Therapy,, Biomaterials Science
- Axonal Mitophagy in Retinal Ganglion Cells,, Cell Communication and Signaling
Cell Therapy
- UCalgary Research into Reindeer Antlers Could Help Unlock Secret of Human Limb Regeneration,, University of Calgary
- Brain Repair Mechanisms After Cell Therapy for Stroke,, Brain
- Gene Therapy and Gene Editing Strategies in Inherited Blood Disorders,, Journal of Genetics and Genomics
- In Utero Gene Therapy and its Application in Genetic Hearing Loss,, Advanced Biology
- Chimeric Cell Therapy Transfers Healthy Donor Mitochondria in Duchenne Muscular Dystrophy,, Stem Cell Reviews and Reports
- Surface Nanocoating of Bacteria as a Versatile Platform to Develop Living Therapeutics,, Nature Protocols
- Retraction Notices Are Getting Clearer — but Progress Is Slow,, Nature
- Genetically Engineered Hypoimmunogenic Cell Therapy,, Nature Reviews Bioengineering
Organoid
- Kidney Disease Modeling with Organoids and Organs-on-Chips,, Annual Review of Biomedical Engineering
- Brain Chimeroids Reveal Individual Susceptibility to Neurotoxic Triggers,, Nature
- Characterization, In Vitro Elderly Digestion, and Organoids Cell Uptake of Curcumin-Loaded Nanoparticles,, Food Chemistry
- Biofabrication Strategies for Cardiac Tissue Engineering,, Current Opinion In Biotechnology
- 3D Embedded Bioprinting of Large-Scale Intestine with Complex Structural Organization and Blood Capillaries,, Biofabrication
- Early Human Fetal Lung Atlas Reveals the Temporal Dynamics of Epithelial Cell Plasticity,, Nature Communications
- Synaptic Plasticity in Human Thalamocortical Assembloids,, Cell Reports
- Liver and Bile Duct Organoids and Tumoroids,, Biomedicine & Pharmacotherapy
3D Cellular Self-Assembly on Optical Disc-Imprinted Nanopatterns,, Lab On A Chip
June 2024
ESC and iPSC
- Capturing Totipotency in Human Cells through Spliceosomal Repression,, (Cell)
- Applications, Challenges, and Prospects of Induced Pluripotent Stem Cells for Vascular Disease,, (Molecules and Cells)
- X-chromosome Inactivation in Human iPSCs Provides Insight into X-Regulated Gene Expression in Autosomes,, (Genome Biology)
- Advances and Challenges in Modeling Inherited Peripheral Neuropathies Using iPSCs,, (Experimental & Molecular Medicine)
- The Relationship between Nanoscale Genome Organization and Gene Expression in Mouse Embryonic Stem Cells during Pluripotency Transition,, (Nucleic Acids Research)
- Molecular Mechanism of BMP Signal Control by Twisted Gastrulation,, (Nature Communications)
Neural
- Developmental Origin of Oligodendrocytes Determines Their Function in the Adult Brain,, (Nature Neuroscience)
- Protein Translation Rate Determines Neocortical Neuron Fate,, (Nature Communications)
- The Necroptosis Cell Death Pathway Drives Neurodegeneration in Alzheimer’s Disease,, (Acta Neuropathologica)
- Spinal Inhibitory Neurons Degenerate before Motor Neurons and Excitatory Neurons in a Mouse Model of ALS,, (Science Advances)
- Multiscale Engineering of Brain Organoids for Disease Modeling,, (Advanced Drug Delivery Reviews)
- Myelin Plasticity in the Ventral Tegmental Area Is Required for Opioid Reward,, (Nature)
- Neuronal Activity-Driven O-GlcNAcylation Promotes Mitochondrial Plasticity,, (Developmental Cell)
Cell Therapy
- Transient Growth Factor Expression via mRNA in Lipid Nanoparticles Promotes Hepatocyte Cell Therapy in Mice,, (Nature Communications)
- Heterologous Survey of 130 DNA Transposons in Human Cells Highlights Their Functional Divergence and Expands the Genome Engineering Toolbox,, (Cell)
- Engineering Viral Vectors for Acoustically Targeted Gene Delivery,, (Nature Communications)
- Bioactive-Material-Programmed CAR-T Cell Living Drug for Augmented Immunotherapy against Tumors,, (Cell Reports Physical Science)
- Regenerative Medicine Act Passes Final Reading at Legislature,, (Focus Taiwan)
Organoid
- Next-Generation Modeling of Cancer Using Organoids,, (Cold Spring Harbor Perspectives In Medicine)
- A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development,, (Advanced Healthcare Materials)
- Mice Hepatic Organoids for Modeling Nonalcoholic Fatty Liver Disease and Drug Response,, (Stem Cells and Development)
- A Microfluidic Chip-Based Automated System for Whole-Course Monitoring the Drug Responses of Organoids,, (Analytical Chemistry)
- A Novel Thin Plate Spline Methodology to Model Tissue Surfaces and Quantify Tumor Cell Invasion in Organ-on-Chip Models,, (Slas Discovery)
- First-in-Kind Protocol for Creating Miniature Artificial Brains,, (TECH Explorist)
- iPSC-Derived Hindbrain Organoids to Evaluate Escitalopram Oxalate Treatment Responses Targeting Neuropsychiatric Symptoms in Alzheimer’s Disease,, (Molecular Psychiatry)
- Human Amniotic Mesenchymal Stem Cell-Islet Organoids Enhance the Efficiency of Islet Engraftment in a Mouse Diabetes Model,, (Life Sciences)
May 2024
ESC and IPSC
- Single-Cell 3D Genome Structure Reveals Distinct Human Pluripotent States(Genome Biology)
- The First Two Blastomeres Contribute Unequally to the Human Embryo(Cell)
- Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways(Nature Communications)
- Quantitative Proteomics Reveals the Dynamic Proteome Landscape of Zebrafish Embryos during the Maternal-to-Zygotic Transition(iScience)
- Scientists Are Trying to Get Cows Pregnant with Synthetic Embryos(MIT Technology Review)
- Forward Programming Human Pluripotent Stem Cells into Microglia(Trends in Cell Biology)
- Cabinet Approves Two Draft Bills on Regenerative Medicine(Overseas Community Affairs Council, Republic of China)
- 3D Reconstruction of a Gastrulating Human Embryo(Cell)
Neural
- The Vascular Contribution of Apolipoprotein E to Alzheimer’s Disease(Brain)
- The Role of Cellular Senescence in Neurodegenerative Diseases(Archives Of Toxicology)
- Itaconate Protects Ferroptotic Neurons by Alkylating GPx4 Post Stroke(Cell Death & Differentiation)
- Actomyosin-II Protects Axons from Degeneration Induced by Mild Mechanical Stress(Journal Of Cell Biology
- Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold(Cold Spring Harbor Perspectives In Biology)
- Autism Patient-Derived SHANK2BY29X Mutation Affects the Development of ALDH1A1 Negative Dopamine Neuron(Molecular Psychiatry)
- New Perspective on Sustained Antidepressant Effect: Focus on Neurexins Regulating Synaptic Plasticity(Cell Death Discovery)
- Origin, Identity, and Function of Terminal Schwann Cells(Trends In Neurosciences)
Cell Therapy
- Global Effort Aims to Protect Health and Safety of Human ‘Guinea Pigs’ in Drug Trials(Science Insider)
- RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy(Cell)
- Single-Cell Transcriptome Landscape and Cell Fate Decoding in Human BrainOrganoids after Transplantation(Advanced Science)
- Promoting Alzheimer’s Disease Research and Therapy with Stem Cell Technology(Stem Cell Research & Therapy)
- Mechanism of Action, Potency and Efficacy: Considerations for Cell Therapies(Journal Of Translational Medicine)
- Recent Trends in 3D Bioprinting Technology for Skeletal Muscle Regeneration(Acta Biomaterialia)
- GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor Efficacy(Molecular Therapy)
- First Fetus-to-Fetus Transplant Demonstrated in Rats(Nature News)
Organoid
- Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke(Aging and Disease)
- FinalSpark Launches the First Remote Research Platform Using Human Neurons for Biocomputing(FinalSpark (Businesswire))
- Establishment of Human Hematopoietic Organoids for Evaluation of Hematopoietic Injury and Regeneration Effect(Stem Cell Research & Therapy)
- First Model of the Brain’s Information Highways Developed(Informationsdienst Wissenschaft)
- Cerebral Organoids Display Dynamic Clonal Growth and Tunable Tissue Replenishment(Nature Cell Biology)
- High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid Model(BMC Molecular And Cell Biology)
- Sebaceous Gland Organoid Engineering(Burns & Trauma)
- Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and Applications(Signal Transduction And Targeted Therapy)
April 2024
ESC and IPSC
- A High Efficiency Precision Genome Editing Method with CRISPR in iPSCs(Scientific Reports)
- Development and Application of Haploid Embryonic Stem Cells(Stem Cell Research & Therapy)
- Human Embryonic Genetic Mosaicism and Its Effects on Development and Disease(Nature Genetics)
- Annelid Adult Cell Type Diversity and Their Pluripotent Cellular Origins(Nature Communications)
- Reconstructing Axial Progenitor Field Dynamics in Mouse Stem Cell-Derived Embryoids(Developmental Cell)
- Crispr-Based Editing of Human Pluripotent Stem Cells for Disease Modeling(Stem Cell Reviews and Reports)
- Induced Pluripotent Stem Cells in Cartilage Tissue Engineering: A Literature Review(Bioscience Reports)
- Scientists Made a Six-Legged Mouse Embryo — Here’s Why(Nature)
Neural
- Origin, Identity, and Function of Terminal Schwann Cells(Trends In Neurosciences)
- New Research Suggests Cerebellum May Play Important Role in Autism (UC Davis Health)
- Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons(Small)
- An Improved Method for Generating Human Spinal Cord Neural Stem Cells(Experimental Neurology)
- Neurofilaments as Biomarkers in Neurological Disorders — towards Clinical Application(Nature Reviews Neurology)
- Autophagy and Exosomes; Inter-Connected Maestros in Alzheimer’s Disease(Inflammopharmacology)
- Immunological Aspects of Central Neurodegeneration(Cell Discovery)
- The Endotoxin Hypothesis of Alzheimer’s Disease(Molecular Neurodegeneration)
Cell Therapy
- First Fetus-to-Fetus Transplant Demonstrated in Rats(Nature News)
- Cell Culture on Suspended Fiber for Tissue Regeneration: A Review(International Journal Of Biological Macromolecules)
- Expression and Processing of Mature Human Frataxin after Gene Therapy in Mice(Scientific Reports)
- This Startup Wants To Be OpenAI Of Stem Cell Therapy, Targets $250B Market(Forbes)
- Mitochondrial DNA as a Target for Analyzing the Biodistribution of Cell Therapy Products(Scientific Reports)
- The Dual Role of Mesenchymal Stem Cells in Apoptosis Regulation(Cell Death & Disease)
- Xcell Biosciences Strengthens Cell and Gene Therapy Collaboration with Labcorp(Xcell Biosciences, Inc. (BusinessWire))
Organoid
- Replacing Animal Testing With Stem Cell-Organoids: Advantages and Limitations(Stem Cell Reviews And Reports)
- Antisense Oligonucleotide Therapeutic Approach for Timothy Syndrome(Nature)
- Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone(Cell Reports)
- Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction(Biomaterials Research)
- Uncharted Territory: Ethical Questions Cloud Fetal Brain Organoid Research(Brain Tomorrow)
- Promising Preclinical Models for Lung Cancer Research—Lung Cancer Organoids: A Narrative Review(Translational Lung Cancer Research)
- Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons(Nature Communications)
- Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone(Cell Reports)
March 2024
ESC and IPSC
- Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived Neurospheres(Regenerative Therapy)
- Stem Cell Models of Inherited Arrhythmias(Nature Cardiovascular Research)
- iPSC-Derived Models for Anorexia Nervosa Research(Trends in Molecular Medicine)
- Fetal Tissue Research Gains in Importance as Roadblocks Multiply(STAT News)
- Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency(International Journal Of Stem Cells)
- Will These Reprogrammed Elephant Cells Ever Make a Mammoth?(Nature)
- Embryonic Stem Cell Transplant Showing Safety in 12 Patients(Parkinson’s News Today)
Neural
- Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection(Cell)
- The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act(Journal Of Neurophysiology)
- Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’s(Science)
- Contrasting Somatic Mutation Patterns in Aging Human Neurons and Oligodendrocytes(Cell)
- Updates on Mouse Models of Alzheimer’s Disease(Molecular Neurodegeneration)
- Neuropathogenesis-on-Chips for Neurodegenerative Diseases(Nature Communications)
- U of T Startup Targets Harmful Side Effect of Cancer Treatment(University of Toronto)
- Computer scientist Wins NSF CAREER Award to Advance Alzheimer’s Research Using AI(Wake Forest University)
- Neuronal Dynamics Direct Cerebrospinal Fluid Perfusion and Brain Clearance(Nature)
Cell Therapy
- Nanomaterials Boost CAR-T Therapy for Solid Tumors(Advanced Healthcare Materials)
- A Humanized Mouse Model for Adeno-Associated Viral Gene Therapy(Nature Communications)
- Why Is The FDA Concerned About Secondary Cancers After CAR T Cells?(Forbes)
- Synthetic Receptor Scaffolds Significantly Affect the Efficiency of Cell Fate Signals(Scientific Reports)
- Targeted Nonviral Delivery of Genome Editors In Vivo(Proceedings Of The National Academy Of Sciences Of The United States Of America)
- Emerging Strategies for Nanomedicine in Autoimmunity(Advanced Drug Delivery Reviews)
- Scripps Research Scientists Honored With Prestigious CZI Awards to Address Diseases Tied to Aging(Scripps Research)
Organoid
- Past and Future of Alveolar Organoids for Lung Regenerative Medicine(Stem Cells)
- Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine(Stem Cell Reviews And Reports)
- Establishment of Patient-Derived Organoids for Guiding Personalized Therapies in Breast Cancer Patients(International Journal Of Cancer)
- Organ-on-Chip Models for Infectious Disease Research(Nature Microbiology)
- Cholangiocyte Organoids to Study Drug-Induced Injury(BMC)
- Bioengineering Toolkits for Potentiating Organoid Therapeutics(Advanced Drug Delivery Reviews)
- Cellular Reprogramming as a Tool to Model Human Aging in a Dish(Nature Communications)
- Vascularized Organoid-on-a-Chip: Design, Imaging, and Analysis(Angiogenesis)
February 2024
ESC and IPSC
- Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons(Journal Of Proteome Research)
- Cellular Reprogramming as a Tool to Model Human Aging in a Dish (Nature Communications)
- Epigenetic Reprogramming in the Transition from Pluripotency to Totipotency(Journal of Cell Physiology)
- A Single-Cell Time-Lapse of Mouse Prenatal Development From Gastrula to Birth(Nature)
- Pluripotent Stem Cell-Based Cardiac Regenerative Therapy for Heart Failure(Journal Of Molecular And Cellular Cardiology)
- China Conducts First Nationwide Review of Retractions and Research Misconduct(Nature News)
- Induced-Pluripotent Stem Cells and Neuroproteomics as Tools for Studying Neurodegeneration(Academic Radiology)
- Improving Stem Cell Research(Harvard University)
Neural
- Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid(Nature)
- Neuralink Brain Chip: Advance Sparks Safety and Secrecy Concerns(Nature)
- GFAP-Isoforms in the Nervous System: Understanding the Need for Diversity(Current Opinion in Cell Biology)
- Dissecting the Spatiotemporal Diversity of Adult Neural Stem Cells(Molecular Systems Biology)
- New Rabies Viral Resources for Multi-Scale Neural Circuit Mapping(Molecular Psychiatry)
- Identification of Direct Connections between the Dura and the Brain(Nature)
- 3D Printer Creates Brain Tissue That Acts like the Real Thing(Science)
- Mitochondrial Stress: A Key Role of Neuroinflammation in Stroke(Journal of Neuroinflammation)
Cell Therapy
- Gene Therapy in Glioblastoma Multiforme: Can It Be a Role Changer?(Heliyon)
- Inibitory CARs Fail to Protect From Immediate T Cell Cytotoxicity(Molecular Therapy)
- In ‘Major Milestone,’ FDA Approves First Cell Therapy for Solid Tumors(STAT News)
- Gene Therapy Allows a Deaf Child to Hear for the First Time(Nature Italy)
- Host Brain Environmental Influences on Transplanted Medial Ganglionic Eminence Progenitors(Scientific Reports)
- Naturally Occurring T Cell Mutations Enhance Engineered T Cell Therapies(Fractals-Complex Geometry Patterns And Scaling In Nature And Society)
- Roles of Exosomes in Immunotherapy for Solid Cancers(Cell Death & Disease)
Organoid
- The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth Orbit(Stem Cells And Development)
- Comparing Stem Cells, Transdifferentiation, and Brain Organoids as Tools for Psychiatric Research(Translational Psychiatry)
- Advanced Lung Organoids for Respiratory System and Pulmonary Disease Modeling(Journal of Tissue Engineering)
- A Growth Factor-Reduced Culture System for Colorectal Cancer Organoids(Cancer Letters)
- Chromatin Remodeling in Patient-Derived Colorectal Cancer Models(Advanced Science)
- Shaping the Neurovascular Unit Exploiting Human Brain Organoids(Molecular Neurobiology)
- Live Organoid Cyclic Imaging(Advanced Science)
- Characterizing Human Astrocyte Calcium Signaling in a Cerebral Organoid(Biophysical Journal)
January 2024
ESC &iPSC
- Hallmarks of Stemness in Mammalian Tissues https://www.stemcellsciencenews.com/newsletter/219117/ (Cell Stem Cell)
- FOXO1-Mediated Lipid Metabolism Maintains Mammalian Embryos in Dormancy https://www.stemcellsciencenews.com/newsletter/219186/ (Nature Cell Biology)
- DNA Methylation Restricts Coordinated Germline and Neural Fates in Embryonic Stem Cell Differentiation https://www.stemcellsciencenews.com/newsletter/219185/ (Nature Structural & Molecular Biology)
- XIST Directly Regulates X-Linked and Autosomal Genes in Naive Human Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219250/ (Cell)
- Mitotic Bookmarking Redundancy by Nuclear Receptors in Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219390/ (Nature Structural & Molecular Biology)
- ROR2 Expression Predicts Human-Induced Pluripotent Stem Cell Differentiation into Neural Stem/Progenitor Cells and GABAergic Neurons https://www.stemcellsciencenews.com/newsletter/219597/ (Scientific Reports)
- Generation of Three Isogenic Human Induced Pluripotent Stem Cell Lines from Normal Neonate Skin Fibroblasts https://www.stemcellsciencenews.com/newsletter/219595/ (Stem Cell Research)
- Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/219593/ (Cell Reports)
- Cloned Rhesus Monkey Lives to Adulthood for First Time https://www.stemcellsciencenews.com/newsletter/219801/ (Nature News)
- Lineage Regulators TFAP2C and NR5A2 Function as Bipotency Activators in Totipotent Embryos https://www.stemcellsciencenews.com/newsletter/219996/ (Nature Structural & Molecular Biology)
- ZFP281 Controls Transcriptional and Epigenetic Changes Promoting Mouse Pluripotent State Transitions via DNMT3 and TET1 https://www.stemcellsciencenews.com/newsletter/220028/ (Developmental Cell)
- Telomere Dynamics in Human Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/220209/ (Cell Cycle)
- The Impact of Induced Pluripotent Stem Cells in Animal Conservation https://www.stemcellsciencenews.com/newsletter/220205/ (Veterinary Research Communications)
Neural
- SpaceX Returns Vital Life Science Research Sponsored by the ISS National Lab https://www.stemcellsciencenews.com/newsletter/219008/ (ISS National Lab)
- Shigella Virulence Protein VirG Is a Broadly Protective Antigen and Vaccine Candidate https://www.stemcellsciencenews.com/newsletter/219023/ (NPJ Vaccines)
- Combined Small-Molecule Treatment Accelerates Maturation of Human Pluripotent Stem Cell-Derived Neurons https://www.stemcellsciencenews.com/newsletter/219022/ (Nature Biotechnology)
- Human Cerebellar Organoids with Functional Purkinje Cells https://www.stemcellsciencenews.com/newsletter/219114/ (Cell Stem Cell)
- The Long-Term Effects of Heated Tobacco Product Exposure on the Central Nervous System in a Mouse Model of Prodromal Alzheimer’s Disease https://www.stemcellsciencenews.com/newsletter/219054/ (Scientific Reports)
- Synaptic-Like Transmission between Neural Axons and Arteriolar Smooth Muscle Cells Drives Cerebral Neurovascular Coupling https://www.stemcellsciencenews.com/newsletter/219229/ (Nature Neuroscience)
- Yap/Taz Activity Is Associated with Increased Expression of Phosphoglycerate Dehydrogenase That Supports Myoblast Proliferation https://www.stemcellsciencenews.com/newsletter/219228/ (Cell And Tissue Research)
- Predicting Myosin Heavy Chain Isoform from Post-Dissection Fiber Length in Human Skeletal Muscle Fibers https://www.stemcellsciencenews.com/newsletter/219225/ (American Journal Of Physiology-Cell Physiology)
- Microglia Enhance Post-Anesthesia Neuronal Activity by Shielding Inhibitory Synapses https://www.stemcellsciencenews.com/newsletter/219271/ (Nature Neuroscience)
- Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
- Neocortical Neurogenesis in Development and Evolution—Human-Specific Features https://www.stemcellsciencenews.com/newsletter/219377/ (Journal of Comparative Neurology)
- Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids https://www.stemcellsciencenews.com/newsletter/219468/ (Cell Death Discovery)
- First Brain Organoids Grown from Fetal Tissue Offer Window on Development https://www.stemcellsciencenews.com/newsletter/219523/ (Science)
- Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson’s Disease https://www.stemcellsciencenews.com/newsletter/219671/ (Science Advances)
- IFITM3 Promotes Glioblastoma Stem Cell-Mediated Angiogenesis via Regulating JAK/STAT3/bFGF Signaling Pathway https://www.stemcellsciencenews.com/newsletter/219772/ (Cell Death & Disease)
- Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin https://www.stemcellsciencenews.com/newsletter/219773/ (Journal Of Pathology)
- The Role of IL-6 in Neurodegenerative Disorders https://www.stemcellsciencenews.com/newsletter/219840/ (Neurochemical Research)
- TREM2 Variants That Cause Early Dementia and Increase Alzheimer’s Disease Risk Affect Gene Splicing https://www.stemcellsciencenews.com/newsletter/219838/ (Brain)
- DNA Methylation-Mediated Repression of microRNA-410 Promotes the Growth of Human Glioma Cells and Triggers Cell Apoptosis Through Its Interaction with STAT3 https://www.stemcellsciencenews.com/newsletter/219919/ (Scientific Reports)
- SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence https://www.stemcellsciencenews.com/newsletter/220096/ (Cell Stem Cell)
- Modeling the Neuroimmune System in Alzheimer’s and Parkinson’s Diseases https://www.stemcellsciencenews.com/newsletter/220168/ (Journal of Neuroinflammation)
Organoid
- Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction https://www.stemcellsciencenews.com/newsletter/219017/ (Biomicrofluidics)
- Human Apical-Out Nasal Organoids Reveal an Essential Role of Matrix Metalloproteinases in Airway Epithelial Differentiation https://www.stemcellsciencenews.com/newsletter/219027/ (Nature Communications)
- High-Throughput Deconvolution of 3D Organoid Dynamics at Cellular Resolution for Cancer Pharmacology with Cellos https://www.stemcellsciencenews.com/newsletter/219116/ (Nature Communications)
- Analysis of Off-Tumor Toxicities of T Cell-Engaging Bispecific Antibodies via Donor-Matched Intestinal Organoids and Tumoroids https://www.stemcellsciencenews.com/newsletter/219115/ (Nature Biomedical Engineering)
- Kidney Organoid Models Reveal Cilium-Autophagy Metabolic Axis as a Therapeutic Target for PKD Both In Vitro and In Vivo https://www.stemcellsciencenews.com/newsletter/219113/ (Cell Stem Cell)
- Spatiotemporal Modulation of Growth Factors Directs the Generation of Multilineage Mouse Embryonic Stem Cell-Derived Mammary Organoids https://www.stemcellsciencenews.com/newsletter/219112/ (Developmental Cell)
- EGFR-Activated Myofibroblasts Promote Metastasis of Pancreatic Cancer https://www.stemcellsciencenews.com/newsletter/219111/ (Cancer Cell)
- Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids https://www.stemcellsciencenews.com/newsletter/219187/ (Science Of The Total Environment)
- Human Fetal Brain Self-Organizes Into Long-Term Expanding Organoids https://www.stemcellsciencenews.com/newsletter/219253/ (Cell)
- Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
- A Disulfidptosis-Related lncRNAs Signature in Hepatocellular Carcinoma: Prognostic Prediction, Tumor Immune Microenvironment and Drug Susceptibility https://www.stemcellsciencenews.com/newsletter/219320/ (Scientific Reports)
- Human Conjunctiva Organoids To Study Ocular Surface Homeostasis and Disease https://www.stemcellsciencenews.com/newsletter/219475/ (Cell Stem Cell)
- Stem Cell Investigations to Improve Cancer Treatment Among Payloads Flying on Axiom Space’s Third Private Astronaut Mission https://www.stemcellsciencenews.com/newsletter/219474/ (ISS National Laboratory)
- Organoids Derived From Patients Provide a New Opportunity for Research and Individualized Treatment of Malignant Peritoneal Mesothelioma https://www.stemcellsciencenews.com/newsletter/219471/ (Molecular Cancer)
- In Vitro Models for Investigating Intestinal Host-Pathogen Interactions https://www.stemcellsciencenews.com/newsletter/219472/ (Advanced Science)
- Uniform Cerebral Organoid Culture on a Pillar Plate by Simple and Reproducible Spheroid Transfer From an Ultralow Attachment Well Plate https://www.stemcellsciencenews.com/newsletter/219470/ (Biofabrication)
- Precancerous Nature of Intestinal Metaplasia With Increased Chance of Conversion and Accelerated DNA Methylation https://www.stemcellsciencenews.com/newsletter/219469/ (Gut)
- Micro instrumentation for Brain Organoids https://www.stemcellsciencenews.com/newsletter/219647/ (Advanced Healthcare Materials)
- Bioassembly of Multicellular Spheroids to Mimic Complex Tissue Structure Using Surface-Modified Magnetized Nanofibers https://www.stemcellsciencenews.com/newsletter/219689/ (Biofabrication)
- Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture https://www.stemcellsciencenews.com/newsletter/219889/ (Biomacromolecules)
- Establishment of Tumor Microenvironment-Preserving Organoid Model from Patients with Intracranial Meningioma https://www.stemcellsciencenews.com/newsletter/220164/ (Cancer Cell International)
December 2023
Neural News
- The Neurobiology of SARS-CoV-2 Infection(Nature Reviews Neuroscience)
- Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments(EMBO Molecular Medicine)
- Targeting Synapse Function and Loss for Treatment of Neurodegenerative Diseases(Nature Reviews Drug Discovery)
- White Matter Injury across Neurodegenerative Disease(Trends In Neurosciences)
- Human-Specific Features and Developmental Dynamics of the Brain N-glycome(Science Advances)
- Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles(Scientific Reports)
- Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout Mice(Neurochemical Research)
- Econazole Selectively Induces Cell Death in NF1-Homozygous Mutant Tumor Cells(Cell Reports Medicine)
Organoid News
- Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments(EMBO Molecular Medicine)
- A Rapid and Stable Spontaneous Reprogramming System of Spermatogonial Stem Cells to Pluripotent State(Cell & Bioscience)
- Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles(Scientific Reports)
- Applications of Lung Cancer Organoids in Precision Medicine: From Bench to Bedside(Cell Communication and Signaling)
- The Impact of Extracellular Matrix on the Precision Medicine Utility of Pancreatic Cancer Patient-Derived Organoids(JCI Insight)
- In Vitro Modeling of the Human Dopaminergic System Using Spatially Arranged Ventral Midbrain–Striatum–Cortex Assembloids(Nature Methods)
- Single-Organoid Analysis Reveals Clinically Relevant Treatment-Resistant and Invasive Subclones in Pancreatic Cancer(NPJ Precision Oncology)
- 3D Hepatic Organoid Production from Human Pluripotent Stem Cells(Differentiation)
- Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer(Cancer Letters)
- Adult Dental Epithelial Stem Cell-Derived Organoids Deposit Hydroxylapatite Biomineral(International Journal of Oral Science)
- Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness(Biofabrication)
ESC & iPSC
- The Circadian Regulator PER1 Promotes Cell Reprogramming by Inhibiting Inflammatory Signaling From Macrophages(PLOS Biology)
- NAT10-Mediated ac4C Modification Promotes Ectoderm Differentiation of Human Embryonic Stem Cells via Acetylating NR2F1 mRNA(Cell Proliferation)
- Hypoblast From Human Pluripotent Stem Cells Regulates Epiblast Development(Nature)
- Synthetic Genetic Circuits To Uncover the OCT4 Trajectories of Successful Reprogramming of Human Fibroblasts(Science Advances)
- A Human Embryonic Limb Cell Atlas Resolved in Space and Time(Nature)
- Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb Loops(Nature Communications)
- Evaluating the In Vitro Developmental Toxicity Potency of a Series of Petroleum Substance Extracts Using New Approach Methodologies (NAMs)(Archives Of Toxicology)
- Applications of Plant-made Fibroblast Growth Factor for Human Pluripotent Stem Cells(Stem Cells And Development)
- Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs(Biotechnology And Bioengineering)
- Utility of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells for Pharmacokinetic, Toxicological, and Immunological Studies(Biochemical And Biophysical Research Communications)
- A Patterned Human Primitive Heart Organoid Model Generated by Pluripotent Stem Cell Self-Organization(Nature Communications)
- In Vitro Production of Naked Mole-Rats’ Blastocysts From Non-Breeding Females Using In Vitro Maturation and Intracytoplasmic Sperm Injection(Scientific Reports)
November 2023
ESC & iPSC News
- Metabolic Plasticity Sustains the Robustness of Caenorhabditis elegans Embryogenesis (EMBO Reports) https://www.stemcellsciencenews.com/newsletter/216547/
- The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells (Advanced Science) https://www.stemcellsciencenews.com/newsletter/216809/
- A Novel Perfusion Bioreactor Promotes the Expansion of Pluripotent Stem Cells in a 3D-Bioprinted Tissue Chamber (Biofabrication) https://www.stemcellsciencenews.com/newsletter/216803/
- NR5A2 Connects Zygotic Genome Activation to the First Lineage Segregation in Totipotent Embryo(Cell Research) https://www.stemcellsciencenews.com/newsletter/217008/
- Generation of Glucocorticoid-Producing Cells Derived from Human Pluripotent Stem Cells (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/217006/
- Mammalian Oocytes Store Proteins for the Early Embryo on Cytoplasmic Lattices (Cell) https://www.stemcellsciencenews.com/newsletter/217003/
- Generation, Characterization, and Differentiation of Induced Pluripotent Stem-Like Cells in the Domestic Cat (Reproduction & Development) https://www.stemcellsciencenews.com/newsletter/217088/
- Small Molecule-Mediated Reprogramming of Xenopus Blastula Stem Cells to a Neural Crest State (Developmental Biology) https://www.stemcellsciencenews.com/newsletter/217085/
- This Hybrid Baby Monkey Is Made of Cells from Two Embryos (Nature) https://www.stemcellsciencenews.com/newsletter/217226/
- Single-Cell, Whole-Embryo Phenotyping of Mammalian Developmental Disorders (Nature) https://www.stemcellsciencenews.com/newsletter/217353/
- Generation of Induced Pluripotent Stem Cell Lines IRMBi003-A and IRMBi003-B from a Healthy Donor to Model Alzheimer’s Disease (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217745/
- Generation of an NCS1 Gene Knockout Human Induced Pluripotent Stem Cell Line Using CRISPR/Cas9 (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217746/
- Use of 2D Minilungs from Human Embryonic Stem Cells to Study the Interaction of Cryptococcus neoformans with the Respiratory Tract (Microbes And Infection) https://www.stemcellsciencenews.com/newsletter/218128/
- Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones (FEBS Open Bio) https://www.stemcellsciencenews.com/newsletter/218127/
- Generation of Induced Pluripotent Stem Cell Line (RCMGi012-a) From Fibroblasts of Patient With Mucopolysaccharidosis Type VI (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/218126/
Cell Therapy News
- CAR T Cell Design-Dependent Remodeling of the Brain Tumor-Immune Microenvironment Modulates Tumor-Associated Macrophages and Anti-Glioma Activity (Cancer Research Communications) https://www.stemcellsciencenews.com/newsletter/217570/
- Implications of High Tumor Burden on Chimeric Antigen Receptor T Cell Immunotherapy (JAMA Oncology) https://www.stemcellsciencenews.com/newsletter/217588/
- Anti-TACI Single and Dual-Targeting CAR T Cells Overcome BCMA Antigen Loss in Multiple Myeloma (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217569/
- CAR T Cells for Treating Autoimmune Diseases (RMD Open) https://www.stemcellsciencenews.com/newsletter/218023/
- Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures – a Multicentric, Randomized, Open Phase IIa Study (Stem Cells Translational Medicine) https://www.stemcellsciencenews.com/newsletter/218019/
- Genetic Retargeting of E3 Ligases to Enhance CAR T Cell Therapy (Cell Chemical Biology) https://www.stemcellsciencenews.com/newsletter/218018/
- An In Vitro Model of the Macrophage-Endothelial Interface to Characterize CAR T-cell Induced Cytokine Storm (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216840/
- Smart Nanoparticles for Cancer Therapy (Signal Transduction and Targeted Therapy) https://www.stemcellsciencenews.com/newsletter/216992/
- AT7867 Promotes Pancreatic Progenitor Differentiation of Human iPSCs (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/216989/
- Transplanting Old Organs Promotes Senescence in Young Recipients (American Journal Of Transplantation) https://www.stemcellsciencenews.com/newsletter/216988/
- Injectable Supramolecular Hydrogels for In Situ Programming of CAR-T Cells towards Solid Tumor Immunotherapy (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217350/
Neural Cell News
- iPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer (Nature) https://www.stemcellsciencenews.com/newsletter/216764/
- Neuronal TIMP2 Regulates Hippocampus-Dependent Plasticity and Extracellular Matrix Complexity (Molecular Psychiatry) https://www.stemcellsciencenews.com/newsletter/216828/
- A Purkinje Cell to Parabrachial Nucleus Pathway Enables Broad Cerebellar Influence over the Forebrain (Nature Neuroscience) https://www.stemcellsciencenews.com/newsletter/216884/
- A Neurodegeneration Checkpoint Mediated by REST Protects against the Onset of Alzheimer’s Disease (Nature Communications) https://www.stemcellsciencenews.com/newsletter/216883/
- A Spinal Cord Neuroprosthesis for Locomotor Deficits Due to Parkinson’s Disease (Nature Medicine) https://www.stemcellsciencenews.com/newsletter/216959/
- Selective Plasticity of Fast and Slow Excitatory Synapses on Somatostatin Interneurons in Adult Visual Cortex (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217048/
- Peptide-Based Approaches to Directly Target Alpha-Synuclein in Parkinson’s Disease (Molecular Neurodegeneration) https://www.stemcellsciencenews.com/newsletter/217202/
- STING Signaling in the Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges (Neuron) https://www.stemcellsciencenews.com/newsletter/217203/
- Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures (Brain Behavior And Immunity) https://www.stemcellsciencenews.com/newsletter/217199/
- The Circadian Clock Time Tunes Axonal Regeneration (Cell Metabolism) https://www.stemcellsciencenews.com/newsletter/217272/
- Targeted Suppression of mTORC2 Reduces Seizures across Models of Epilepsy (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217307/
- Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson’s Disease Mouse Model (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217305/
- Altered Corollary Discharge Signaling in the Auditory Cortex of a Mouse Model of Schizophrenia Predisposition (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217399/
- Molecular Biomarkers for Vascular Cognitive Impairment and Dementia (Nature Reviews Neurology) https://www.stemcellsciencenews.com/newsletter/217469/
- Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy (Proceedings Of The National Academy Of Sciences Of The United States Of America) https://www.stemcellsciencenews.com/newsletter/217558/
- Characterization of Neuromuscular Transmission and Projections of Muscle Motor Neurons in the Rat Stomach (American Journal Of Physiology-Gastrointestinal And Liver Physiology) https://www.stemcellsciencenews.com/newsletter/217662/
- Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids (Frontiers In Neuroscience) https://www.stemcellsciencenews.com/newsletter/217763/
- Sequential Appetite Suppression by Oral and Visceral Feedback to the Brainstem (Nature) https://www.stemcellsciencenews.com/newsletter/217762/
- Third-Generation Rabies Viral Vectors Allow Nontoxic Retrograde Targeting of Projection Neurons with Greatly Increased Efficiency (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/218092/
- Disruption of the Autism Gene and Chromatin Regulator KDM5A Alters Hippocampal Cell Identity (Science Advances) https://www.stemcellsciencenews.com/newsletter/218132/
Organoid Cell News
- The Drug Efficacy Testing in 3D Cultures Platform Identifies Effective Drugs for Ovarian Cancer Patients (NPJ Precision Oncology) https://www.stemcellsciencenews.com/newsletter/216766/
- Using Picoliter Droplet Deposition to Track Clonal Competition in Adherent and Organoid Cancer Cell Cultures (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216765/
- Cancer-on-Chip Models for Metastasis: Importance of the Tumor Microenvironment (Trends In Biotechnology) https://www.stemcellsciencenews.com/newsletter/216829/
- SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs (Experimental & Molecular Medicine) https://www.stemcellsciencenews.com/newsletter/216841/
- In-Organoid Single-Cell CRISPR Screening Reveals Determinants of Hepatocyte Differentiation and Maturation (Genome Biology) https://www.stemcellsciencenews.com/newsletter/217081/
- Potential Application of Intestinal Organoids in Intestinal Diseases (Stem Cell Reviews and Reports) https://www.stemcellsciencenews.com/newsletter/217179/
- Ascorbate Protects Human Kidney Organoids From Damage Induced by Cell-Free Hemoglobin (Disease Models & Mechanisms) https://www.stemcellsciencenews.com/newsletter/217178/
- Hepatitis C Virus Infects and Perturbs Liver Stem Cells (mBio) https://www.stemcellsciencenews.com/newsletter/217177/
- Patient-Derived Organoids Identify Tailored Therapeutic Options and Determinants of Plasticity in Sarcomatoid Urothelial Bladder Cancer (npj Precision Oncology) https://www.stemcellsciencenews.com/newsletter/217175/
- Reconstruction of Dynamic Mammary Mini Gland In Vitro for Normal Physiology and Oncogenesis (Nature Methods) https://www.stemcellsciencenews.com/newsletter/217171/
- Human Intestinal Organoids From Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin and Proliferation (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217172/
- Cochlear Organoids Reveal Transcriptional Programs of Postnatal Hair Cell Differentiation from Supporting Cells (Cell Reports) https://www.stemcellsciencenews.com/newsletter/217311/
- Modular 3D Printed Platform for Fluidically Connected Human Brain Organoid Culture (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217310/
- Recent Advances in Lung Organoid Development and Applications in Disease Modeling (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217398/
- Single-Cell Transcriptomics Stratifies Organoid Models of Metabolic Dysfunction-Associated Steatotic Liver Disease (EMBO Journal) https://www.stemcellsciencenews.com/newsletter/217395/
- Human Intestinal Organoids: Modeling Gastrointestinal Physiology and Immunopathology – Current Applications and Limitations (European Journal Of Immunology) https://www.stemcellsciencenews.com/newsletter/217496/
- Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217605/
- Engineered Synthetic Matrices for Human Intestinal Organoid Culture And Therapeutic Delivery (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217768/
- Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/217766/
- NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation (Development) https://www.stemcellsciencenews.com/newsletter/217797/
- Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects (Cell) https://www.stemcellsciencenews.com/newsletter/218150/
October2023
- The Role of Zfp352 in the Regulation of Transient Expression of 2-Cell Specific Genes in Mouse Embryonic Stem Cells (Genes to Cells)
- Telomeric DNA Breaks in Human Induced Pluripotent Stem Cells Trigger ATR-Mediated Arrest and Telomerase-Independent Telomere Damage Repair (Journal of Molecular Cell Biology)
- Transcriptomic Analysis of PADI4 Target Genes during Multi-Lineage Differentiation of Embryonic Stem Cells(Philosophical Transactions Of The Royal Society B-Biological Sciences)
- The Efficient Generation of Functional Human Hepatocytes from Chemically Induced Pluripotent Stem Cells (Cell Proliferation)
- Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation Technique (Biomedical Materials)
- Functional Interrogation of Twenty Type 2 Diabetes-Associated Genes Using Isogenic Human Embryonic Stem Cell-Derived β-Like Cells (Cell Metabolism)
- BRD9-Mediated Control of the TGF-β/Activin/Nodal Pathway Regulates Self-Renewal and Differentiation of Human Embryonic Stem Cells and Progression of Cancer Cells (Nucleic Acids Research)
- Investigation of Immune-Related Diseases Using Patient-Derived Induced Pluripotent Stem Cells(Inflammation and Regeneration)
Cell Therapy News
- A Deregulated m6A Writer Complex Axis Driven by BRD4 Confers an Epitranscriptomic Vulnerability in Combined DNA Repair–Targeted Therapy (Proceedings Of The National Academy Of Sciences Of The United States Of America)
- Preclinical Development of a Chimeric Antigen Receptor T Cell Therapy Targeting FGFR4 in Rhabdomyosarcoma (Cell Reports Medicine)
- Involving Stemness Factors to Improve CAR T-Cell-Based Cancer Immunotherapy (Medical Oncology)
- Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells (ACS Nano)
- Sustained Long-Term Disease Correction in a Murine Model of MPSII Following Stem Cell Gene Therapy (Molecular Therapy-Methods & Clinical Development)
- Mind the GAP: RASA2 and RASA3 GTPase-Activating Proteins As Gatekeepers of T Cell Activation and Adhesion (Trends in Immunology)
- Synthetic Transcription Factor Engineering for Cell and Gene Therapy (Trends In Biotechnology)
- NKGen Biotech Announces FDA Clearance of Investigational New Drug Application for SNK01 NK Cell Therapy to Treat Alzheimer’s Disease (NKGen Biotech Inc.)
Neural News
- Fe65-Engineered Neuronal Exosomes Encapsulating Corynoxine-B Ameliorate Cognition and Pathology of Alzheimer’s Disease (Signal Transduction and Targeted Therapy)
- Clinical Trial Links Oncolytic Immunoactivation to Survival in Glioblastoma (Nature)
- Crosstalk between Small-Cell Lung Cancer Cells and Astrocytes Mimics Brain Development to Promote Brain Metastasis (Nature Cell Biology)
- A Humanized Chemogenetic System Inhibits Murine Pain-Related Behavior and Hyperactivity in Human Sensory Neurons (Science Translational Medicine)
- Models for Evaluating Glioblastoma Invasion along White Matter Tracts (Trends in Biotechnology)
- Subventricular Zone Cytogenesis Provides Trophic Support for Neural Repair in a Mouse Model of Stroke (Nature Communications)
- Microglia and Complement Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease (Nature Medicine)
- This Is the Largest Map of the Human Brain Ever Made (Nature)
- HMGA2 Directly Mediates Chromatin Condensation in Association with Neuronal Fate Regulation (Nature Communications)
- Dexmedetomidine Alleviates Cognitive Impairment by Promoting Hippocampal Neurogenesis via BDNF/TrkB/CREB Signaling Pathway in Hypoxic–Ischemic Neonatal Rats (CNS Neuroscience & Therapeutics)
Organoid News
- Establishment of a 96-Well Transwell System Using Primary Human Gut Organoids to Capture Multiple Quantitative Pathway Readouts (Scientific Reports)
- Efficient Genetic Editing of Human Intestinal Organoids Using Ribonucleoprotein-Based CRISPR (Disease Models & Mechanisms)
- Mapping Oto-Pharyngeal Development in a Human Inner Ear Organoid Model (Development) A Scalable Human Islet 3D-Culture Platform Maintains Cell Mass and Function Long-Term for Transplantation (American Journal Of Transplantation)
- Tissue Morphology Influences the Temporal Program of Human Brain Organoid Development (Cell Stem Cell)
- Characterization and AAV-Mediated CRB Gene Augmentation in Human Derived CRB1KO and CRB1KOCRB2+/- Retinal Organoids (Molecular Therapy-Methods & Clinical Development)
- Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency (eLife)
- Unlocking the Potential of Organoids in Cancer Treatment and Translational Research: An Application of Cytologic Techniques (Cancer Cytopathology)
- Induced Regeneration of Articular Cartilage: Identification of a Dormant Regeneration Program for a Non-regenerative Tissue Icon for the Forest of Biologists (Development)
- Systematic Review: Predictive Value of Organoids in Colorectal Cancer(Scientific Reports)
September 2023
- GATA1 Deletion in Human Pluripotent Stem Cells Increases Differentiation Yield and Maturity of Neutrophils (iScience)
- CHK1-CDC25A-CDK1 Regulate Cell Cycle Progression and Protect Genome Integrity in Early Mouse Embryos (EMBO Reports)
- Recent Advances in Regulating the Proliferation or Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (Stem Cell Research & Therapy)
- Comparison of miRNA Transcriptome of Exosomes in Three Categories of Somatic Cells with Derived iPSCs (Scientific Data)
- Directed Differentiation of Human Pluripotent Stem Cells into Articular Cartilage Reveals Effects Caused by Absence of WISP3, the Gene Responsible for Progressive Pseudorheumatoid Arthropathy of Childhood (Cytotherapy)
- Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells (CRISPR Journal)
- KLF4 Facilitates Chromatin Accessibility Remodeling in Porcine Early Embryos (Science China Life Sciences)
- DUX4 Expression in Cancer Induces a Metastable Early Embryonic Totipotent Program (Cell Reports)
- Uncovering the Role of FOXA2 in the Development of Human Serotonin Neurons (Advanced Science)
- Human Trials of Artificial Wombs Could Start Soon. Here’s What You Need to Know (Nature News)
- Cardiac Involvement in Patient-Specific Induced Pluripotent Stem Cells of Myotonic Dystrophy Type 1: Unveiling the Impact of Voltage-Gated Sodium Channels (Frontiers in Physiology)
- Deepening the Role of Excitation/Inhibition Balance in Human iPSCs-Derived Neuronal Networks Coupled to MEAs during Long-Term Development (Journal of Neural Engineering)
- Accelerated Differentiation of Human Induced Pluripotent Stem Cells into Regionally Specific Dorsal and Ventral Spinal Neural Progenitor Cells for Application in Spinal Cord Therapeutics (Frontiers in Neuroscience)
- Mini-TCRs: Truncated T Cell Receptors to Generate T Cells from Induced Pluripotent Stem Cells (Molecular Therapy-Methods & Clinical Development)
- Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification (Nature Communications)
- Induced Pluripotent Stem Cells: Ex Vivo Models for Human Diseases Due to Mitochondrial DNA Mutations (Journal of Biomedical Science)
- TOBF1 Modulates Mouse Embryonic Stem Cell Fate through Regulating Alternative Splicing of Pluripotency Genes (Cell Reports)
August 2023
- Manipulating and Studying Gene Function in Human Pluripotent Stem Cell Models (FEBS Letters)
- Rat Post-Implantation Epiblast-Derived Pluripotent Stem Cells Produce Functional Germ Cells (Cell Reports Methods)
- NAT10-Mediated N4-Acetylcytidine mRNA Modification Regulates Self-Renewal in Human Embryonic Stem Cells (Nucleic Acids Research)
- Country-Specific Regulation and International Standardization of Cell-Based Therapeutic Products Derived from Pluripotent Stem Cells (Stem Cell Reports)
- Female Naïve Human Pluripotent Stem Cells Carry X Chromosomes with Xa-Like and Xi-Like Folding Conformations (Science Advances)
- A Fast Chemical Reprogramming System Promotes Cell Identity Transition through a Diapause-Like State (Nature Cell Biology)
- Distinct Characteristics of Two Types of Alternative Lengthening of Telomeres in Mouse Embryonic Stem Cells (Nucleic Acids Research)
- The MORC2 p.S87L Mutation Reduces Proliferation of Pluripotent Stem Cells Derived from a Patient with the Spinal Muscular Atrophy-Like Phenotype by Inhibiting Proliferation-Related Signaling Pathways (Journal Of Immunotherapy)
- Utilizing Human Induced Pluripotent Stem Cells to Study Atrial Arrhythmias in the Short QT Syndrome (Journal Of Molecular And Cellular Cardiology)
- Reprogramming iPSCs to Study Age-Related Diseases: Models, Therapeutics, and Clinical Trials (Mechanisms Of Ageing And Development)
- Cell-Type-Specific Regulation of APOE and CLU Levels in Human Neurons by the Alzheimer’s Disease Risk Gene SORL1 (Cell Reports)
- Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway (Tissue Engineering And Regenerative Medicine)
- Control of Stem Cell Renewal and Fate by YAP and TAZ (Nature Reviews Molecular Cell Biology)
- Haspin Balances the Ratio of Asymmetric Cell Division Through Wnt5a and Regulates Cell Fate Decisions in Mouse Embryonic Stem Cells (Cell Death Discovery)
- Effects of Low Doses of Methylmercury (MeHg) Exposure on Definitive Endoderm Cell Differentiation in Human Embryonic Stem Cells (Archives Of Toxicology)
- Improved Cryopreservation of Human Induced Pluripotent Stem Cell (iPSC) and iPSC Derived Neurons Using Ice-Recrystallization Inhibitors (Stem Cells)
- Wnt and BMP Signaling Direct Anterior/Posterior Differentiation in Aggregates of Mouse Embryonic Stem Cells (Biology Open)
- The Induction of Parathyroid Cell Differentiation from Human Induced Pluripotent Stem Cells Promoted via TGF-α/EGFR Signaling (Stem Cells And Development)
- Single-Molecule Tracking of Nanog and Oct4 in Living Mouse Embryonic Stem Cells Uncovers a Feedback Mechanism of Pluripotency Maintenance (EMBO Journal)
July 2023
- Building Human Artery and Vein Endothelial Cells from Pluripotent Stem Cells, and Enduring Mysteries Surrounding Arteriovenous Development (Seminars in Cell & Developmental Biology)
- Derivation and Characteristics of Induced Pluripotent Stem Cells from a Patient with Acute Myelitis (Frontiers In Cell And Developmental Biology)
- Chemical Genomics Reveals Targetable Programs of Human Cancers Rooted in Pluripotency (Cell Chemical Biology)
- ZMYM2 Is Essential for Methylation of Germline Genes and Active Transposons in Embryonic Development (Nucleic Acids Research)
- Artificial Induction of Circadian Rhythm by Combining Exogenous BMAL1 Expression and Polycomb Repressive Complex 2 Inhibition in Human Induced Pluripotent Stem Cells (Cellular and Molecular Life Sciences)
- Effective SARS-CoV-2 Replication of Monolayers of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells (Scientific Reports)
- Human Trophoblast Stem Cell-State Acquisition from Pluripotent Stem Cells and Somatic Cells (Current Opinion in Genetics & Development)
- Restricting Epigenetic Activity Promotes the Reprogramming of Transformed Cells to Pluripotency in a Line-Specific Manner (Cell Death Discovery)
- Crosstalk between RNA m6A and DNA Methylation Regulates Transposable Element Chromatin Activation and Cell Fate in Human Pluripotent Stem Cells (Nature Genetics)
June 2023
- Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts(Nature Communications)
- Human Embryonic Stem Cells Exert Antitumor Effects on Prostate Cancer Cells in a Co-Culture Microenvironment(Frontiers In Oncology)
- LIS1 RNA-Binding Orchestrates the Mechanosensitive Properties of Embryonic Stem Cells in AGO2-Dependent and Independent Ways(Nature Communications)
- Identification and Functional Evaluation of Alternative Splice Variants of Dax1 in Mouse Embryonic Stem Cells(Stem Cells And Development)
- The Circadian Clock CRY1 Regulates Pluripotent Stem Cell Identity and Somatic Cell Reprogramming(Cell Reports)
- On-Chip Real-Time Impedance Monitoring of hiPSC-Derived and Artificial Basement Membrane-Supported Endothelium(Bioactive Materials)
- Suspension Culture Improves iPSC Expansion and Pluripotency Phenotype(Current Stem Cell Research & Therapy)
- Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo(Nature Communications)
- Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts(Nature Communications)
- Harnessing Three-Dimensional (3D) Cell Culture Models for Pulmonary Infections: State of the Art and Future Directions(Naunyn-Schmiedebergs Archives Of Pharmacology)
- Generation of an Induced Pluripotent Stem Cell Lines NSHDMUi001-A from Patients with Type 2 Diabetes(Stem Cell Research)
- GSK-3α/β and MEK Inhibitors Assist the Microenvironment of Tumor Initiation(Cytotechnology)
- A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells(Nature)
- Self-Patterning of Human Stem Cells into Post-implantation Lineages(Nature)
- Most Advanced Synthetic Human Embryos Yet Spark Controversy(Nature News)
- Sequential and Directional Insulation by Conserved CTCF Sites Underlies the Hox Timer in Stembryos(Nature Genetics)
- Cell-Membrane-Coated and Cell-Penetrating Peptide-Conjugated Trimagnetic Nanoparticles for Targeted Magnetic Hyperthermia of Prostate Cancer Cells [ACS Applied Materials & Interfaces]
- Comparative Landscape of Genetic Dependencies in Human and Chimpanzee Stem Cells(Cell)
- Overcoming the H4K20me3 Epigenetic Barrier Improves Somatic Cell Nuclear Transfer Reprogramming Efficiency in Mice(Cell Proliferation)
- Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like Cells(Stem Cell Reviews And Reports)
- An O-GlcNAc Transferase Pathogenic Variant Linked to Intellectual Disability Affects Pluripotent Stem Cell Self-Renewal(Disease Models & Mechanisms)
- Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson’s Disease Patients Carrying the Heterozygous Mutations c.815G > a (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1)Stem Cell Research)
- Generation of Induced Pluripotent Stem Cell Line (XWHNi002-a) from a Female with APP Gene Mutation (Stem Cell Research)
- Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons(Cellular Reprogramming)
- Human Prostate Organoid Generation and the Identification of Prostate Development Drivers Using Inductive Rodent Tissues(Development)
- A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells (Nature)
- Self-Patterning of Human Stem Cells into Post-implantation Lineages (Nature)
May 2023
- Identification of an Adipose Tissue-Resident Pro-Preadipocyte Population(Cell Reports)
- Optogenetic Manipulation Identifies the Roles of ERK and AKT Dynamics in Controlling Mouse Embryonic Stem Cell Exit from Pluripotency(Developmental Cell)
- Human Embryo Science: Can the World’s Regulators Keep Pace?(Nature News)
- Esrrb Guides Naive Pluripotent Cells through the Formative Transcriptional Programme(Nature Cell Biology)
- Acoel Single-Cell Atlas Reveals Expression Dynamics and Heterogeneity of Adult Pluripotent Stem Cells(Nature Communications)
- Hypo immune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques
- (Nature Biotechnology)https://www.nature.com/articles/s41587-023-01784-x
- Embryonic Stem Cell ERK, AKT, Plus STAT3 Response Dynamics Combinatorics Are Heterogeneous but NANOG State Independent(Stem Cell Reports)
- Generation of iPSC-Derived Human Forebrain Organoids Assembling Bilateral Eye Primordia(Nature Protocols)
- A CRISPR-Engineered Isogenic Model of the 22q11.2 A-B Syndromic Deletion(Scientific Reports)
- Cellular Population Dynamics Shape the Route to Human Pluripotency
- (Nature Communications)https://www.nature.com/articles/s41467-023-37270-w
- The Effect of Vitamin D3 and Valproic Acid on the Maturation of Human Induced Pluripotent Stem Cell-Derived Enterocyte-Like Cells(Stem Cells)https://academic.oup.com/stmcls/advance-article-abstract/doi/10.1093/stmcls/sxad042/7179740?redirectedFrom=fulltext&login=false
- RNA Stability Controlled by m6A Methylation Contributes to X-to-Autosome Dosage Compensation in Mammals(Nature Structural & Molecular Biology)
- Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo(Nature Communications)
- Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement(Stem Cells Translational Medicine)
- Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells(Cell Discovery)
- USP7 Represses Lineage Differentiation Genes in Mouse Embryonic Stem Cells by Both Catalytic and Noncatalytic Activities(Science Advances)
- Extensive Programmed Centriole Elimination Unveiled inC. elegansEmbryos(Science Advances)
- Ablation of ZC3H11A Causes Early Embryonic Lethality and Dysregulation of Metabolic Processes
- [Proceedings Of The National Academy Of Sciences Of The United States Of America]
- Reprogramming of Three-Dimensional Chromatin Organization in the Early Embryo
- (Current Opinion In Structural Biology)
- Mesodermal FGF and BMP Govern the Sequential Stages of Zebrafish Thyroid Specification(Development)
- Differentiation and Single-Cell RNA-Seq Analyses of Human Pluripotent-Stem-Cell-Derived Renal Organoids(Star Protocols)
- The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells(CRISPRJournal)https://www.liebertpub.com/doi/10.1089/crispr.2023.0013
- First Female Arab Astronaut Reaches ISS for Historic Mission to Conduct Stem Cell & Cancer Research(The Free Press Journal)
- Is Space the Place for Stem Cell Manufacturing? Scientists Will Soon Test That on the ISS(FierceBiotech)
- Modulation of WNT, Activin/Nodal, and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation during Human iPSC Differentiation(Stem Cells)
- MutSα and MutSβ as Size-Dependent Cellular Determinants for Prime Editing in Human Embryonic Stem Cells(Molecular Therapy – Nucleic Acids)
- Generation of Stable Integration-Free Pig Induced Pluripotent Stem Cells under Chemically Defined Culture Condition(Cell Proliferation)
- Parallel Genome-Wide CRISPR Screens to Identify State-Dependent Self-Renewal Regulators of Mouse Embryonic Stem Cells(Stem Cells and Development)
- CRISPR/Cas9 Assisted Stem Cell Therapy in Parkinson’s Disease(Biomaterials Research)
- The RNA Cap Methyltransferases RNMT and CMTR1 Co-Ordinate Gene Expression during Neural Differentiation(Biochemical Society Transactions)
- BCL2 Is a Major Regulator of Haploidy Maintenance in Murine Embryonic Stem Cells(Cell Proliferation)
- Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy(Cell Stem Cell)
- Establishment of Bovine Trophoblast Stem Cells (Cell Report)
- https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00450-3
- Chemically Defined Production of Tri-Lineage Human iPSC-Derived Cardiac Spheroids(Current Protocols)
- Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System(Cell Reports Methods)
- A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells(Endocrine Connections)
- Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca2+-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous RYR2 and SCN10A Variants(Philosophical Transactions Of The Royal Society B-Biological Sciences)
- The Generation and Properties of Human Cortical Organoids as a Disease Model for Malformations of Cortical Development(Neural Regeneration Research)
- Efficient and Rapid Fluorescent Protein Knock-In with Universal Donors in Mouse Embryonic Stem Cells(Development)
- A Desert lncRNA HIDEN Regulates Human Endoderm Differentiation via Interacting with IMP1 and Stabilizing FZD5 mRNA(Genome Biology)
- Modeling Human Skeletal Development Using Human Pluripotent Stem Cells
- (Proceedings Of The National Academy Of Sciences Of The United States Of America)
April 2023
- A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation inHTRA1(Inflammation and Regeneration)
- Development of substrates for the culture of human pluripotent stem cells(Biomaterials Science)
- Albumin-Based Solution Is the Ideal Post-thawing Suspension Medium for Cord Blood Hematopoietic Stem Cells: A Stability and Proliferative Evaluation(Transfusion)
- Brain p3-Alcβ Peptide Restores Neuronal Viability Impaired by Alzheimer’s Amyloid β-Peptide(EMBO Molecular Medicine)
- Extracellular Vesicles in Tumor Angiogenesis and Resistance to Anti-Angiogenic Therapy(Cancer Science)
- Gene Editing to Prevent Ventricular Arrhythmias Associated with Cardiomyocyte Cell Therapy(Cell Stem Cell)
- Hematopoietic Stem-Cell Gene Therapy Is Associated with Restored White Matter Microvascular Function in Cerebral Adrenoleukodystrophy(Nature Communications)
- Interleukin-1 Receptor Antagonist: A Promising Cytokine against Human Squamous Cell Carcinomas(Heliyon)
- Modelling Hyperexcitability in Human Cerebral Cortical Organoids: Oxygen/Glucose Deprivation Most Effective Stimulant(Heliyon)
- Pluripotent, Germ Cell Competent Adult Stem Cells Underlie Cnidarian Regenerative Ability and Clonal Growth(Current Biology)
- Rif1Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells(Stem Cell Reviews and Reports)
- Scalable generation of sensory neurons from human pluripotent stem cells(STEM CELL REPORTS)
- Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells(STEM CELL REPORTS)
- Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder(Molecular Psychiatry)
- A hydrogel model of the human blood-brain barrier using differentiated stem cells(PLOS ONE)
- Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation(ACS Nano)
- Induced pluripotent stem cell technology in bone biology(Science Direct)
- Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes(Cell Reports)
- Engineering Alignment Has Mixed Effects on Human Induced Pluripotent Stem Cell Differentiated Cardiomyocyte Maturation(Tissue Engineering Part A)
- Secretive Derived from Hypoxia Preconditioned Mesenchymal Stem Cells Promote Cartilage Regeneration and Mitigate Joint Inflammation via Extracellular Vesicles(Bioactive Materials)
- Skeletal Muscle Gene Expression Dysregulation in Long-Term Spaceflights and Aging Is Clock-Dependent(NPJ Microgravity)
- Advancing Cell Therapy for Neurodegenerative Diseases(Cell Stem Cell)
- A Multi-Omics Integrative Analysis Based on CRISPR Screens Re-defines the Pluripotency Regulatory Network in ESCs(Communications Biology)
- Cancer Neuroscience: State of the Field, Emerging Directions(Cell)
- CRISPR-Based Functional Genomics Screening in Human-Pluripotent-Stem-Cell-Derived Cell Types(Cell Genomics)
- DC Vaccine Enhances CAR-T Cell Antitumor Activity by Overcoming T Cell Exhaustion and Promoting T Cell Infiltration in Solid Tumors(Clinical And Translational Oncology)
- Decoding the Molecular Crosstalk between Grafted Stem Cells and the Stroke-Injured Brain(Cell Reports)
- Human iPSC-Derived Neural Progenitor Cells Secreting GDNF Provide Protection in Rodent Models of ALS and Retinal Degeneration(Stem Cell Reports)
- MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4(Current Medical Science)
- Mechanisms of Resistance and Treatment of Relapse After CAR T-Cell Therapy for Large B-Cell Lymphoma and Multiple Myeloma(Transplantation And Cellular Therapy)
- Progress and Emerging Techniques for Biomaterial-Based Derivation of Mesenchymal Stem Cells (MSCs) from Pluripotent Stem Cells (PSCs)(Biomaterials Research)
- Transforming the Understanding of Brain Immunity(Science)
- AnIn VivoNeuroimmune Organoid Model to Study Human Microglia Phenotypes (Cell)
- Directing iPSC Differentiation into iTenocytes Using Combined Scleraxis Overexpression and Cyclic Loading (Journal of Orthopaedic Research)
- Autologous Mesenchymal Stem Cells Offer a New Paradigm for Salivary Gland Regeneration(International Journal of Oral Science)
- Hypoimmune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques(Nature Biotechnology)
- Rescue of GM3 Synthase Deficiency by Spatially Controlled, rAAV-MediatedST3GAL5Delivery (JCI Insight)
- Effects of HDAC Inhibitors on Neuroblastoma SH-SY5Y Cell Differentiation Into Mature Neurons via the Wnt Signaling Pathway (BMC Neuroscience)
- Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy(Cell Stem Cell)
- Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System(Cell Reports Methods)
- A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells (Endocrine connections)
- Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca2+-Homeostasis in Clinical Arrhythmia Associated with Combined HeterozygousRYR2andSCN10AVariants (Philosophical Transactions Of The Royal Society B-Biological Sciences)
- Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect against Abdominal Aortic Aneurysm Formation by Inhibiting NET-Induced Ferroptosis (Communications Biology)
- Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells(Cell Discovery) https://www.nature.com/articles/s41421-023-00538-y
March 2023
- Dipeptidyl peptidase 4 Promotes Survival and Stemness of Acute Myeloid Leukemia Stem Cells(Cell Reports)
- Generation of Self-Organized Autonomic Ganglion Organoids from Fibroblasts(iScience)
- Human Gene-Engineered Calreticulin Mutant Stem Cells Recapitulate MPN Hallmarks and Identify Targetable Vulnerabilities(Leukemia)
- Melatonin-Mediated FKBP4 Downregulation Protects against Stress-Induced Neuronal Mitochondria Dysfunctions by Blocking Nuclear Translocation of GR(Cell Death & Disease)
- Patient-Derived Spheroids and Patient-Derived Organoids Simulate Evolutions of Lung Cancer(Heliyon)
- Psychedelics Promote Neuroplasticity through the Activation of Intracellular 5-HT2A Receptors(Science)
- A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 Infection(Nature Cell Biology)
- Apoptosis Inhibition Enhances Induced Pluripotent Stem Cell Generation during T Cell Reprogramming(Biochemical and Biophysical Research Communications)
- Clinical Use of CAR T-cells in Treating Acute Lymphoblastic Leukemia(Transfusion And Apheresis Science)
- Dying Transplanted Neural Stem Cells Mediate Survival Bystander Effects in the Injured Brain(Cell Death & Disease)
- Fibroblast Heterogeneity: Keystone of Tissue Homeostasis and Pathology in Inflammation and Aging(Frontiers In Immunology)
- Generation of Functional Oocytes from Male MiceIn Vitro(Nature)
- Highly Efficient and Rapid Generation of Human Pluripotent Stem Cells by Chemical Reprogramming(Cell Stem Cell)
- Improved Survival of Patients with Primary Plasma Cell Leukemia with VRd or Daratumumab-based Quadruplets: A Multicenter Study by the Greek Myeloma Study Group(American Journal Of Hematology)
- Implantation of Engineered Human Microvasculature to Study Human Infectious Diseases in Mouse Models(iScience)
- The Novel GATA1-Interacting Protein HES6 Is an Essential Transcriptional Cofactor for Human Erythropoiesis(Nucleic Acids Research)
- Very Small Embryonic-Like Stem Cells Transform into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test(Stem Cells)
February 2023
- A Molecular Characterization and Clinical Relevance of Microglia-Like Cells Derived from Patients with Panic Disorder(Translational Psychiatry)
- Bioengineering Approaches to Promote Maturity in Human Skeletal Muscle Constructs(Biophysical Journal)
- Cancer Stem Cells: Recent Insights and Therapies(Biochemical Pharmacology)
- Supports Meso-Endoderm Differentiation from Mouse Embryonic Stem Cells(Nature Communications)
- Inflammation and DNA Damage: Cause, Effect or Both(Nature Reviews Rheumatology)
- iPSC-Based Modeling of THD Recapitulates Disease Phenotypes and Reveals Neuronal Malformation(EMBO Molecular Medicine)
- Lnc956-TRIM28-HSP90B1 Complex on Replication Forks Promotes CMG Helicase Retention to Ensure Stem Cell Genomic Stability and Embryogenesis(Science Advances)
- Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials(Transplantation And Cellular Therapy)
- NANOGP1, a Tandem Duplicate of NANOG, Exhibits Partial Functional Conservation in Human Naïve Pluripotent Stem Cells(Development)
- Nanosheet Coating Improves Stability of Human Pluripotent Stem Cell Culture on Glass Substrates(Biochemical and Biophysical Research Communications)
- Reversal of Aging-Associated Increase in Myelopoiesis and Expression of Alarmins by Angiotensin-(1–7)(Scientific Reports)
- Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment(Nature Communications)
- Transgenic Skin Biomechanical Properties Following First Lifesaving Epidermal Regeneration Using Combined Gene and Cell Therapy(Journal of the German Society of Dermatology)
January 2023
- Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and Prospects(Tissue and Cell)
- Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1(ACS Nano)
- Corneal Stem Cells Niche and Homeostasis Impacts in Regenerative Medicine; Concise Review(European Journal of Ophthalmology)
- Cross-Species Transcriptomic Atlas of Dorsal Root Ganglia Reveals Species-Specific Programs for Sensory Function(Nature Communications)
- Endothelial Cell-Derived Exosomes Boost and Maintain Repair-Related Phenotypes of Schwann Cells via miR199-5p to Promote Nerve Regeneration(Journal Of Nanobiotechnology)
- Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome(Stem Cell Reviews and Reports)
- Human iPSC-Derived Preclinical Models to Identify Toxicity of Tumor-Specific T Cells with Clinical Potential(Molecular Therapy-Methods & Clinical Development)
- Photoreceptor Laminin Drives Differentiation of Human Pluripotent Stem Cells to Photoreceptor Progenitors That Partially Restore Retina Function(Molecular Therapy)
- Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression(Nature Cell Biology)
- Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate under BMP4 Induction from Human Pluripotent Stem Cells(Stem Cells)
- The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture Models(Advanced Science)
- Transcriptional and Functional Effects of Lithium in Bipolar Disorder iPSC-Derived Cortical Spheroids(Molecular Psychiatry)
- Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the Brain(Journal of Neuroinflammation)
December 2022
·RNA Degradation Eliminates Developmental Transcripts during Murine Embryonic Stem Cell Differentiation via CAPRIN1-XRN2
· Embryonic Origins of Adult Pluripotent Stem Cells
·Bulk RNA sequencing analysis of developing human induced pluripotent cell-derived retinal organoids
·Effect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell linein vitro
·Stress-Induced Reversible Cell-Cycle Arrest Requires PRC2/PRC1-Mediated Control of Mitophagy inDrosophilaGermline Stem Cells and Human iPSCs
· Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells
·Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells
·CD34dimcells identified as pluripotent stem cell-derived definitive hemogenic endothelium purified using bone morphogenetic protein 4
·A Reference Human Induced Pluripotent Stem Cell Line for Large-Scale Collaborative Studies
· The Consequences of Recurrent Genetic and Epigenetic Variants in Human Pluripotent Stem Cells
·Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density
November 2022
- Long-Range Axonal Projections of Transplanted Mouse Embryonic Stem Cell-Derived Hypothalamic Neurons into Adult Mouse Brain(PLoS One)
- Modeling Placental Development and Disease Using Human Pluripotent Stem Cells(Placenta)
- Transcription Factor Antagonism Regulates Heterogeneity in Embryonic Stem Cell States(Molecular Cell)
- Membrane Potential Drives the Exit from Pluripotency and Cell Fate Commitment via Calcium and mTOR(Nature Communications)
- Lamin A/C-dependent Chromatin Architecture Safeguards Naïve Pluripotency to Prevent Aberrant Cardiovascular Cell Fate and Function(Nature Communications)
- Virtual Cells in a Virtual Microenvironment Recapitulate Early Development-Like Patterns in Human Pluripotent Stem Cell Colonies(Stem Cell Reports)
- Stabilization of hESCs in Two Distinct Substrates along the Continuum of Pluripotency(iScience)
- Acute Severe Hypoxia Induces Apoptosis of Human Pluripotent Stem Cells by a HIF-1α and P53 Independent Mechanism(Scientific Reports)
- Intermediate Cells ofIn VitroCellular Reprogramming andIn VivoTissue Regeneration Require Desmoplakin(Science Advances)
- Transient Inhibition of p53 Enhances Prime Editing and Cytosine Base-Editing Efficiencies in Human Pluripotent Stem Cells(Nature Communications)
- Stabilization of Cell-Cell Adhesions Prevents Symmetry Breaking and Locks In Pluripotency in 3D Gastruloids(Stem Cell Reports)
- Nucleosome Breathing Facilitates Cooperative Binding of Pluripotency Factors Sox2 and Oct4 to DNA(Biophysical Journal)
- Therapeutic Function of a Novel Rat Induced Pluripotent Stem Cell Line in a 6-OHDA-Induced Rat Model of Parkinson’s Disease(International Journal of Molecular Medicine])
- Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells That Are Defective in Self-Renewal(International Journal of Stem Cells)
- Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development(Stem Cells Translational Medicine)
October 2022
World’s first stem cell treatment for spina bifida delivered during fetal surgery!
- Identification of Stable Housekeeping Genes for Induced Pluripotent Stem Cells and -Derived Endothelial Cells for Drug Testing (Scientific Reports)https://www.nature.com/articles/s41598-022-20435-w
- TGFβ Superfamily Signaling Regulates the State of Human Stem Cell Pluripotency and Capacity to Create Well-Structured Telencephalic Organoids (Stem Cell Reports)https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00422-2
- The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells (Molecules and Cells)https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2022.2042
- Human Cellular Models for Retinal Disease: From Induced Pluripotent Stem Cells to Organoids (Retina-the Journal of Retinal and Vitreous Diseases)https://journals.lww.com/retinajournal/Abstract/2022/10000/HUMAN_CELLULAR_MODELS_FOR_RETINAL_DISEASE__From.1.aspx
- Super-Enhancers Conserved within Placental Mammals Maintain Stem Cell Pluripotency (Proceedings of the National Academy of Sciences of the United States of America)https://www.pnas.org/doi/10.1073/pnas.2204716119
- High Glucose Impairs Osteogenic Differentiation of Embryonic Stem Cells via Early Diversion of Beta-Catenin from Forkhead Box O to T Cell Factor Interaction (Birth Defects Research)https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2085
September2022
- Retinoic Acid Delays Initial Photoreceptor Differentiation and Results in a Highly Structured Mature Retinal Organoid (Stem Cell Research & Therapy)https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03146-x
- Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells (Bioengineering & Translational Medicine)https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10390
- Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage (NPJ Regenerative Medicine)https://www.nature.com/articles/s41536-022-00241-8
- CTCF Acetylation at Lysine 20 Is Required for the Early Cardiac Mesoderm Differentiation of Embryonic Stem Cells (Cell Regeneration)https://cellregeneration.springeropen.com/articles/10.1186/s13619-022-00131-w
- Evolutionary Origin of Vertebrate OCT4/POU5 Functions in Supporting Pluripotency (Nature Communications)https://www.nature.com/articles/s41467-022-32481-z
- Dominant Role of DNA Methylation over H3K9me3 for IAP Silencing in Endoderm (Nature Communications)https://www.nature.com/articles/s41467-022-32978-7
- LncRNA-Smad7 Mediates Cross-Talk between Nodal/TGF-β and BMP Signaling to Regulate Cell Fate Determination of Pluripotent and Multipotent Cells (Nucleic Acids Research)https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac780/6711145
- Passage Number Affects Differentiation of Sensory Neurons from Human Induced Pluripotent Stem Cells (Scientific Reports)https://www.nature.com/articles/s41598-022-19018-6
- Modeling Urea Cycle Disorders Using iPSCs (NPJ Regenerative Medicine)https://www.nature.com/articles/s41536-022-00252-5
- BuildingIn VitroModels of the Brain To Understand the Role of APOE in Alzheimer’s Disease[Life Science Alliance]https://www.life-science-alliance.org/content/5/11/e202201542
- PFOS Disrupts Key Developmental Pathways during hiPSC Derived Cardiomyocyte Differentiation (In VitroToxicology in Vitro)https://www.sciencedirect.com/science/article/pii/S0887233322001734?via%3Dihub
- Imprinting Fidelity in Mouse iPSCs Depends on Sex of Donor Cell and Medium Formulation (Nature Communications)https://www.nature.com/articles/s41467-022-33013-55
- CRISPR-Cas9 Screen in Human Embryonic Stem Cells to Identify Genes Required for Neural Differentiation (STAR Protocols)https://www.sciencedirect.com/science/article/pii/S2666166722005627?via%3Dihub
- Different Transcriptional Profiles of Human Embryonic Stem Cells Grown in a Feeder-Free Culture System and on Human Foreskin Fibroblast Feeder Layers (Aging-Us)https://www.aging-us.com/article/204282/text
- Fast Generation of Forebrain Oligodendrocyte Spheroids from Human Embryonic Stem Cells by Transcription Factors(iScience)https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901444-4
- METTLing in Stem Cell and Cancer Biology (Stem Cell Reviews and Reports)https://link.springer.com/article/10.1007/s12015-022-10444-7
- A Stem Cell Roadmap of Ribosome Heterogeneity Reveals a Function for RPL10A in Mesoderm Production (Nature Communications)https://www.nature.com/articles/s41467-022-33263-3
- Human PSCs Determine the Competency of Cerebral Organoid Differentiation via FGF Signaling and Epigenetic Mechanisms (iScience)https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901412-2
- Mouse Embryo Model Derived Exclusively from Embryonic Stem Cells Undergoes Neurulation and Heart Development (Cell Stem Cell)https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00377-0
- Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells (Biomacromolecules)https://pubs.acs.org/doi/10.1021/acs.biomac.2c00585
- Acquisition and Maintenance of Pluripotency Are Influenced by Fibroblast Growth Factor, Leukemia Inhibitory Factor, and 2i in Bovine-Induced Pluripotent Stem Cells(Frontiers in Cell and Developmental Biology)https://www.stemcellsciencenews.com/newsletter/194131/
- Recent Advances for Using Human Induced-Pluripotent Stem Cells as Pain-in-a-Dish Models of Neuropathic Pain (Experimental Neurology)https://www.sciencedirect.com/science/article/pii/S0014488622002485?via%3Dihub
- Modeling Metabolic Diseases and Drug Response Using Stem Cells and Organoids (Nature Reviews Endocrinology)https://www.nature.com/articles/s41574-022-00733-z
- Harnessing Conserved Signaling and Metabolic Pathways to Enhance the Maturation of Functional Engineered Tissues (NPJ Regenerative Medicine)https://www.nature.com/articles/s41536-022-00246-3
- Spatial Molecular Anatomy of Germ Layers in the Gastrulating Cynomolgus Monkey Embryo (Cell Reports)https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01105-6
- Modeling Human Extraembryonic Mesoderm Cells Using Naive Pluripotent Stem Cells (Cell Stem Cell)https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00337-X
- Systemic Proteomics and miRNA Profile Analysis of Exosomes Derived from Human Pluripotent Stem Cells (Stem Cell Research & Therapy)https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03142-1
- Robust Genome Editing via modRNA-Based Cas9 or Base Editor in Human Pluripotent Stem Cells (Cell Reports Methods)https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(22)00172-2
- Molecular Convergence between Down Syndrome and Fragile X Syndrome Identified Using Human Pluripotent Stem Cell Models (Cell Reports)https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01136-6
- Modeling Human Multi-Lineage Heart Field Development with Pluripotent Stem Cells (Cell Stem Cell)https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00343-5
- Generation of Human Induced Pluripotential Stem Cells from Individuals with Complex Heterozygous, Isogenic Corrected, and HomozygousBloc1s1Mutations(Stem Cell Research)https://www.sciencedirect.com/science/article/pii/S1873506122002549
August 2022
- DLL4 and VCAM1 Enhance the Emergence of T Cell–Competent Hematopoietic Progenitors from Human Pluripotent Stem Cells (Science Advances)https://www.science.org/doi/10.1126/sciadv.abn5522
- Repeated Intravenous Administration of hiPSC-MSCs Enhance the Efficacy of Cell-Based Therapy in Tissue Regeneration (Communications Biology)https://www.nature.com/articles/s42003-022-03833-8